The Caricature Museum is located in an 18th-century Baroque building in the historic center of Mexico City. It was opened in 1987 to preserve and promote the history of Mexican cartooning, done for both political and entertainment purposes. The historic building it occupies was originally the home of Cristo College, a royal college established in 1612.
The Casa Lamm Cultural Center is the best known landmark in Colonia Roma. It was a house built in the early 20th century when Colonia Roma was a new neighborhood for the wealthy leaving the historic center of Mexico City. In the 1990s, the house was restored to open as a cultural center in 1994, with the aim of making the area a center for the visual arts. Today, it hosts numerous exhibits as well as offering classes, even degrees, in art and literature.
Casa Talavera Cultural Center is located in the La Merced neighborhood of the historic center of Mexico City. The building dates back to either the 16th or early 17th century and was the home of the Marquis de Aguayo. In 1931, it was declared a national monument and in 2002, the space was converted to its present use, administered by the Universidad Autónoma de la Ciudad de México.

The Centro Cultural Bella Epoca is a cultural 3,000 square meter cultural centre in the Condesa neighborhood in Mexico City. It includes the Rosario Castellanos bookshop which carries over 35 thousand different titles, and has a children’s area, a coffee shop, and reading facilities. The Cine Lido art cinema and Galería Luis Cardoza y Aragón art gallery are also housed in the cultural center.

The Centro Cultural de España is located at 18 Guatemala Street in the historic center of Mexico City. In the late 1990s, this old mansion just behind the Cathedral was in ruins when the Mexico City government ceded it to the Spanish government. When restoration work was finished, the new Centro Cultural de España was inaugurated by the king of Spain with the President of Mexico in 2002.
The Fábrica de Artes y Oficios Oriente, better known as FARO or FARO Oriente is a cultural center and training facility located in the Iztapalapa borough of Mexico City. It is the only major cultural facility on this side of the city. It was inaugurated in 2000 with the aim of providing educational and cultural opportunities for some of the most marginalized populations in Mexico City, providing an alternative to gangs and drugs. Today, the facility serves about 320,000 people each year, mostly from Iztapalapa but attracting youth from other areas of Mexico City as well. It provides free classes in various arts, handcrafts and trade skills as well as concerts, art exhibits, book presentations and more. In 2002 it received the Coming Up Taller Award from the United States.

The Falling Man is a sculpture by French artist Auguste Rodin modeled in 1882 and is part of Rodin's emblematic group The Gates of Hell.
The Franz Mayer Museum, in Mexico City opened in 1986 to house, display and maintain Latin America’s largest collection of decorative arts. The collection was amassed by stockbroker and financial professional Franz Mayer, who collected fine artworks, books, furniture, ceramics, textiles and many other types of decorative items over fifty years of his life. A large portion comes from Europe and Asia but most comes from Mexico itself with items dating from the 15th to the 20th centuries. Many pieces in the collection are fine handcrafts, such as textiles and Talavera pottery, and they are important because they are items that often did not survive because most did not consider them worth preserving.

Cacahuamilpa's Grottos is an oil painting finished in 1835 by Jean-Baptiste Louis Gros, after his second visit to the caves in Grutas de Cacahuamilpa National Park, in Guerrero, Mexico. It is now in the Museo Soumaya, Mexico City.
The History of Mexico is a mural in the stairwell of the National Palace in Mexico City by Diego Rivera. Produced between 1929 and 1935, the mural depicts Mexico's history from ancient times to the present, with particular emphasis on the struggles of the common Mexican people fighting against the Spanish, the French, and the dictators that controlled the country at different points in its history.
The Church and Hospital of Jesús Nazareno buildings are located in the Historic center of Mexico City, in México, D. F., Mexico. The hospital is still in operation, housed in a Modernist building, located in front of the original one, and beside the former church. Both historic buildings and their courtyards are 17th-century Spanish colonial era architecture.

Mexican muralism was the promotion of mural painting starting in the 1920s, generally with social and political messages as part of efforts to reunify the country under the post-Mexican Revolution government. It was headed by "the big three" painters, Diego Rivera, José Clemente Orozco and David Alfaro Siqueiros. From the 1920s to the 1970s many murals with nationalistic, social and political messages were created on public buildings, starting a tradition which continues to this day in Mexico and has had impact in other parts of the Americas, including the United States, where it served as inspiration for the Chicano art movement.

The Museo de Arte Popular is a museum in Mexico City, Mexico that promotes and preserves part of the Mexican handcrafts and folk art. Located in the historic center of Mexico City in an old fire house, the museum has a collection which includes textiles, pottery, glass, piñatas, alebrijes, furniture and much more. However, the museum is best known as the sponsor of the yearly, Noche de Alebrijes parade in which the fantastical creatures are constructed on a monumental scale and then paraded from the main plaza or Zocalo to the Angel of Independence monument, competing for prizes.

The Museo Nacional de Arte (MUNAL) is the Mexican national art museum, located in the historical center of Mexico City. The museum is housed in a neoclassical building at No. 8 Tacuba, Col. Centro, Mexico City. It includes a large collection representing the history of Mexican art from the mid-sixteenth century to the mid 20th century. It is recognizable by Manuel Tolsá's large equestrian statue of Charles IV of Spain, who was the monarch just before Mexico gained its independence. It was originally in the Zocalo but it was moved to several locations, not out of deference to the king but rather to conserve a piece of art, according to the plaque at the base. It arrived at its present location in 1979.
The Museo Soumaya is a private museum in Mexico City and a non-profit cultural institution with two museum buildings in Mexico City - Plaza Carso and Plaza Loreto. It has over 66,000 works from 30 centuries of art including sculptures from Pre-Hispanic Mesoamerica, 19th- and 20th-century Mexican art and an extensive repertoire of works by European old masters and masters of modern western art such as Auguste Rodin, Salvador Dalí, Bartolomé Esteban Murillo and Tintoretto. It is called one of the most complete collections of its kind.
The National Palace is the seat of the federal executive in Mexico. Since 2018 it has also served as the official residence for the President of Mexico. It is located on Mexico City's main square, the Plaza de la Constitución. This site has been a palace for the ruling class of Mexico since the Aztec Empire, and much of the current palace's building materials are from the original one that belonged to the 16th-century leader Moctezuma II.

San Ildefonso College currently is a museum and cultural center in Mexico City, considered to be the birthplace of the Mexican muralism movement. San Ildefonso began as a prestigious Jesuit boarding school, and after the Reform War it gained educational prestige again as National Preparatory School. This school and the building closed completely in 1978, then reopened as a museum and cultural center in 1992. The museum has permanent and temporary art and archeological exhibitions in addition to the many murals painted on its walls by José Clemente Orozco, Fernando Leal, Diego Rivera and others. The complex is located between San Ildefonso Street and Justo Sierra Street in the historic center of Mexico City.
The San Pedro y San Pablo College colonial church and school complex built in late 16th and early 17th centuries, located in the historical center of Mexico City district of Mexico City, Mexico.
Santa Teresa la Antigua is a former convent located in the historic center of Mexico City on Licenciado Primo de Verdad #6 just northeast of the city's main plaza. The complex ceased to be a convent in the latter part of the 19th century and has housed the Santa Teresa la Antigua Alternative Art Center since 1989.

Sueño de una tarde dominical en la Alameda Central or Dream of a Sunday Afternoon in the Alameda Central is a mural created by Diego Rivera. It was painted between the years 1946 and 1947, and is the principal work of the Museo Mural Diego Rivera adjacent to the Alameda in the historic center of Mexico City.