
Astounding Space Thrills is a science-fiction webcomic by Steve Conley that ran from 1998 until 2001. Consisting of around 500 pages, Conley made use of GIF images and an early precursor to a "share" button while creating Astounding Space Thrills. The webcomic was first published as a comic book series by Image Comics starting in 2000, and it was remastered as a webcomic in 2016.

Avalon was a webcomic by Josh Phillips set in the fictional city of Avalon, Ontario, Canada. It focused on a group of high school students, and while it was originally gag-a-day, it evolved into a coherent, long-term story with realistic characters. The comic launched on 8 November 1999 and was originally scheduled to end in August 2002. Avalon was a member of Keenspot.

Bobbins is a webcomic written by John Allison. It ran from 21 September 1998 to 3 June 2002, but shifted into reruns with commentary on 17 May 2002. It has made occasional returns in John Allison's website in between his other comics since 2013. Webcomics portal Keenspot kept the Bobbins archive freely accessible online, but the archives eventually moved to Allison's own site.

Boy on a Stick and Slither is a webcomic by Steven L. Cloud. Strips usually feature a short, pithy and sometimes surreal exchange between the title characters. The strip is characterized by dry and cynical humor.

Buzzer Beater is a Japanese manga series written and illustrated by Takehiko Inoue. The series debuted as a webcomic in 1996 and it was also serialized in Shueisha's Monthly Shōnen Jump shortly after its introduction on the web. An anime television series adaptation released in 2005, followed by a second season in 2007.

Dilbert is an American comic strip written and illustrated by Scott Adams, first published on April 16, 1989. It is known for its satirical office humor about a white-collar, micromanaged office with engineer Dilbert as the title character. It has spawned dozens of books, an animated television series, a video game, and hundreds of themed merchandise items. Dilbert Future and The Joy of Work are among the most read books in the series. In 1997, Adams received the National Cartoonists Society Reuben Award and the Newspaper Comic Strip Award for his work. Dilbert appears online and as of 2013 was published daily in 2,000 newspapers in 65 countries and 25 languages.

Doctor Fun is a single-panel, gag webcomic by David Farley. It began in September 1993, making it one of the earliest webcomics, and ran until June 2006. Doctor Fun was part of United Media's website from 1995, but had parted ways by 2003. The comic may have been the longest-running webcomic before it concluded, having run for nearly thirteen years with over 2,600 strips. The webcomic has been compared to The Far Side.

Dork Tower is an online comic created, written and drawn by John Kovalic. It chronicles the lives of a group of geeks living in the fictional town of Mud Bay, Wisconsin. Mud Bay's design is strongly influenced by the author's home town of Madison, Wisconsin. Topics have included role-playing games (RPGs), comic books, video games, and fandom in general. The comic strip began in January 1997 and has made appearances in publications like Dragon magazine, Shadis, and Comic Shop News. Starting in 2000, the strip began web publication roughly three times a week and is featured in Pyramid. The bimonthly comic book made its first appearance in 1998 and features continuing storylines. It has recently gone to full color with issue #32, and it is collected in trade paperback.

Goats is a popular webcomic written and illustrated by Jonathan Rosenberg. The webcomic started April 1, 1997. On April 3, 2006, after nine years drawing the strip, Rosenberg became a full-time cartoonist making his living drawing Goats. In 2010, because of work on Scenes from a Multiverse, Goats was put on hiatus. In 2012 Rosenberg raised more than $55.000 via Kickstarter to print Goats Book IV, relaunch the website and finish the story with Goats Book V. On August 19, 2014, 71 comics and all e-books were republished, while Kickstarter backers have yet to receive any merchandise.

Jane's World was a comic strip by cartoonist Paige Braddock that ran from March 1998 to October 2018. Featuring lesbian and bisexual women characters, the strip stars Jane Wyatt, a young lesbian living in a trailer in Northern California with her straight male roommate, Ethan, and follows her life with her circle of friends, romances, and exes. Shortly after celebrating its 20th anniversary, publication ended with Jane marrying Dorothy.

NetBoy is a webcomic created by Stafford Huyler. Publishing began in May, 1994. Drawn as a stick figure, the comic character NetBoy is an Internet innocent with his greatest joy in life being "fast .GIFs."

Ozy and Millie is a daily comic strip that ran from 1998 to 2008, created by Dana Simpson and syndicated by North America Syndicate and Andrews McMeel Syndication. It follows the adventures of assorted anthropomorphized animals, centering on Ozy and Millie, two young foxes attending North Harbordale Elementary School in Seattle, contending with everyday elementary school issues such as tests and bullies, as well as more surreal situations.

Penny Arcade is a webcomic focused on video games and video game culture, written by Jerry Holkins and illustrated by Mike Krahulik. The comic debuted in 1998 on the website loonygames.com. Since then, Holkins and Krahulik have established their own site, which is typically updated with a new comic strip each Monday, Wednesday, and Friday. The comics are accompanied by regular updates on the site's blog.

Piled Higher and Deeper, is a newspaper and webcomic strip written and drawn by Jorge Cham that follows the lives of several grad students. First published in 1997 when Cham was a grad student himself at Stanford University, the strip deals with issues of life in graduate school, including the difficulties of scientific research, the perils of procrastination, and the complex student–supervisor relationship. As of 2017, the strip's website received 6 million visitors each year.

PvP, also known as Player vs Player, is a longrunning video game webcomic, written and drawn by Scott Kurtz. The webcomic follows the events at a fictional video game magazine company, featuring many running gags and references with a focus on nerd culture. Dylan Meconis was added as a co-writer in 2013.

Real Life is an American webcomic drawn and authored by Maelyn Dean that began on November 15, 1999. After having not been updated since December 10, 2015, the comic continued on September 10, 2018. It stopped updating again from July 16, 2019, and recommenced on June 15, 2020. The comic is loosely based around the lives of fictionalized versions of Dean and her friends, including verbatim conversations, as well as fictional aspects including time travel and mecha combat. Characters regularly break the fourth wall. Real Life focuses on humor related to video games and science fiction, and references internet memes.

Red Meat is a comic strip by Max Cannon. First published in 1989, it has appeared in over 80 newspapers, mainly alternative weeklies and college papers in the United States and in other countries. It has been available online since 1996.

T.H.E. Fox is a furry comic strip by Joe Ekaitis which ran from 1986 to 1998. It is among the earliest online comics, predating Where the Buffalo Roam by over five years. T.H.E. Fox was published on CompuServe, Q-Link and GEnie, and later on the Web as Thaddeus. Despite running weekly for several years, the comic never achieved Ekaitis' goal of print syndication. Updates became less frequent, and eventually stopped altogether.

User Friendly is a webcomic written by J. D. Frazer, also known by his pen name Illiad. Starting in 1997, the strip was one of the earliest webcomics to make its creator a living. The comic is set in a fictional internet service provider and draws humor from dealing with clueless users and geeky subjects. The comic ran seven days a week until 2009 when updates became sporadic, and since 2010 it has been in reruns only.

Jeffrey J. Rowland is the author and artist responsible for Wigu and Overcompensating, two popular webcomics. Originally from Locust Grove, Oklahoma, Rowland now lives in Easthampton, Massachusetts where he continues to work on the two projects, while running TopatoCo, a company which sells merchandise based on his and other artists' comics.