
The Big Bang Theory is an American television sitcom created by Chuck Lorre and Bill Prady, both of whom served as executive producers on the series, along with Steven Molaro. All three also served as head writers. It premiered on CBS on September 24, 2007, and concluded on May 16, 2019, having broadcast 279 episodes over 12 seasons.

Bob Hearts Abishola is an American sitcom television series created by Chuck Lorre, Eddie Gorodetsky, Al Higgins, and Gina Yashere that premiered on September 23, 2019, on CBS. It stars Billy Gardell and Folake Olowofoyeku as the respective title characters, with Christine Ebersole, Matt Jones, Maribeth Monroe, Shola Adewusi, Barry Shabaka Henley, Travis Wolfe Jr., Vernee Watson, Bayo Akinfemi, Anthony Okungbowa, and Gina Yashere in supporting roles. In February 2021, the series was renewed for a third season, which premiered on September 20, 2021.

Cybill is an American television sitcom created by Chuck Lorre, which aired on CBS from January 2, 1995, to July 13, 1998. Starring Cybill Shepherd, the show revolves around the life of Cybill Sheridan, a twice-divorced single mother of two and struggling actress in her 40s, who has never gotten her big show business break. Alicia Witt and Dedee Pfeiffer co-starred as Sheridan's daughters, with Alan Rosenberg and Tom Wopat playing their respective fathers, while Christine Baranski appeared as Cybill's hard-drinking friend Maryann.

Dharma & Greg is an American television sitcom that originally aired on ABC from September 24, 1997, until April 30, 2002, for 119 episodes over five seasons.

Disjointed is an American streaming television comedy series created by David Javerbaum and Chuck Lorre and starring Kathy Bates. Twenty episodes of the series were ordered from Warner Bros. by Netflix, with the first 10 episodes premiering on August 25, 2017. The last 10 episodes were released on January 12, 2018. On February 14, 2018, Netflix canceled the series. It is noteworthy as their first original multi-cam sitcom.

Grace Under Fire is an American sitcom that aired on ABC from September 29, 1993, to February 17, 1998. The show starred Brett Butler as a single mother learning how to cope with raising her three children alone after finally divorcing her abusive husband. The series was created by Chuck Lorre and produced by Carsey-Werner Productions.

The Kominsky Method is an American comedy-drama streaming television series created by Chuck Lorre, that premiered on November 16, 2018, on Netflix. It stars Michael Douglas, Alan Arkin, Sarah Baker, Nancy Travis, Paul Reiser, and Kathleen Turner and follows an aging acting coach who, years earlier, had a brief moment of success as an actor. A second season premiered on October 25, 2019, and a third and final season premiered on May 28, 2021.

Mom is an American television sitcom created by Chuck Lorre, Eddie Gorodetsky and Gemma Baker that ran on CBS from September 23, 2013, to May 13, 2021, lasting eight seasons. Set in Napa, California, it follows dysfunctional daughter/mother duo Christy and Bonnie Plunkett, who, after having been estranged for years while both struggled with addiction, attempt to pull their lives and their relationship together by trying to stay sober and attending Alcoholics Anonymous. It stars Anna Faris and Allison Janney in the leading roles, with Mimi Kennedy, Jaime Pressly, Beth Hall, William Fichtner, Sadie Calvano, Blake Garrett Rosenthal, Matt Jones, French Stewart, and Kristen Johnston in supporting roles.

Two and a Half Men is an American television sitcom that originally aired on CBS for twelve seasons from September 22, 2003, to February 19, 2015. Originally starring Charlie Sheen, Jon Cryer and Angus T. Jones, the series was about a hedonistic jingle writer, Charlie Harper, his uptight brother, Alan and Alan's mischievous son, Jake. After Alan divorces, he and Jake move into Charlie's beachfront Malibu house and complicate Charlie's freewheeling life. In 2010, CBS and Warner Bros. Television reached a multiyear broadcasting agreement for the series, renewing it through at least the 2011–12 season. In February 2011, however, CBS and Warner Bros. decided to end production for the rest of the eighth season after Sheen entered drug rehabilitation and made "disparaging" comments about the series' creator and executive producer Chuck Lorre. Sheen's contract was terminated the following month and he was written out of the show after it was confirmed that he would not be returning to the series. Ashton Kutcher was hired to replace him the following season as Walden Schmidt, a billionaire who buys Charlie's house after his death.

Young Sheldon is an American coming-of-age sitcom television series for CBS created by Chuck Lorre and Steven Molaro. The series, set in the late 1980s and early 1990s, is a spin-off prequel to The Big Bang Theory and begins with the character Sheldon Cooper at the age of nine, living with his family in East Texas and going to high school. Iain Armitage stars as young Sheldon, alongside Zoe Perry, Lance Barber, Montana Jordan, Raegan Revord, and Annie Potts. Matt Hobby was promoted to the main cast starting with the third season. Jim Parsons, who portrays the adult Sheldon Cooper on The Big Bang Theory, narrates the series and serves as an executive producer.