
Abapó is a town in the Santa Cruz Department of Bolivia. The town is just short of the eastern foothills of the Andes mountains, and on the north bank of the Rio Grande, which runs east then turns north to drain into the Amazon Basin.

Ascensión de Guarayos is a town in Bolivia. In 2010 it had an estimated population of 18,816.

Laguna Bahia Toco Largo is a lake in the José Miguel de Velasco Province, Santa Cruz Department, Bolivia. At an elevation of 165 m, its surface area is 6.5 km².

Bellavista Lake is a lake in the San Ignacio de Velasco Municipality, José Miguel de Velasco Province, Santa Cruz Department, Bolivia. At an elevation of 200 m, its surface area is 24.8 km².

Cabezas is a small town in Bolivia, seat of Cabezas Municipality. In 2010 it had an estimated population of 1971.

Laguna Cáceres is a lake in Germán Busch Province, Santa Cruz Department, Bolivia. At an elevation of 150 m, its surface area is 26.5 to 200 km².

Chané Magallanes is a small town in Bolivia. In 2012, it had an estimated population of 686.

Laguna Chaplín is a lake in the San Ignacio de Velasco Municipality, José Miguel de Velasco Province, Santa Cruz Department, Bolivia. At an elevation of 190 m, its surface area is 13 km².
Charagua is a small town in the southern part of Bolivia. It is the principal village of the Cordillera province. Most inhabitants speak Guaraní. The city was briefly occupied by the Paraguayan Army in April 1935, during the last stages of the Chaco War. Charagua consists of two separate towns, the old town and a settlement along the railway track, 3.2 km east.

Chimoré is a village in Santa Cruz Department, Bolivia.

Comarapa is a small town in Bolivia. In 2009 it had an estimated population of 5,793. It is located roughly halfway between Cochabamba and Santa Cruz.

Concepción is a lake in Chiquitos Province, Santa Cruz Department, Bolivia. At an elevation of 248 m, its surface area is 58 to 158 km².

Laguna Consuelo is a lake in the Santa Cruz Department, Bolivia. Its surface area is 2.6 km².

Cotoca is a canton and Municipality of Andrés Ibáñez Province in Santa Cruz Department, Bolivia. The municipality consists of two cantons – Cotoco itself and Puerto Pailas. In 2010 it had an estimated population of 23,951 for the canton and 56,451 for the municipality.
Cuevo is a small town in the Andes in Bolivia. In 2010 it had an estimated population of 2,317.

España Lake is a lake in the Santa Cruz Department, Bolivia. Its surface area is 34 km².

Germán Busch is a province in the Santa Cruz Department, Bolivia. Most of the surface is covered by the Pantanal, the largest wetland area in the world.

The Itonomas River is a river of Bolivia. It is a tributary of the Guaporé (Iténez) River and runs through the departments of Santa Cruz and Beni. Over its course it receives tributaries such as the Quizer River.

Lagunillas is a location in the Santa Cruz Department in Bolivia. It is the seat of the Lagunillas Municipality, the first municipal section of the Cordillera Province.

Limoncito is a small town in the Santa Cruz Department in Bolivia.

Mairana is a small town in Bolivia.

Mineros is a city of Bolivia, capital of the Mineros Municipality of the Santa Cruz Department, 83 km north of the city of Santa Cruz de la Sierra. Due to the policy of the 1960s that forced the indigenous people of the Altiplano to immigrate, 23.3% of the population knows how to speak Quechua.

Montero is the name of a city and a municipality in Santa Cruz, Bolivia, about 50 km north of Santa Cruz de la Sierra. Population 109,503 (2012). Montero has experienced growth in recent decades, becoming an important city in this region.

Nuevo Mundo Lake is a lake in the Beni Department and Santa Cruz Department, Bolivia. At an elevation of 180 m, its surface area is 57.7 km².
Otuquis National Park and Integrated Management Natural Area,, is a national park in the Pantanal ecoregion of southeastern Bolivia.

Pailón is a small town in Bolivia. It is in the second municipal section of the Chinquitos province and is 51 kilometres (32 mi) east of the city Santa Cruz de la Sierra.

The Piray River is a river of Bolivia. Santa Cruz de la Sierra, Bolivia's largest city by population, is located on this river.

Laguna Pistola is a lake in the Santa Cruz Department, Bolivia. Its surface area is 33.52 km² and a shore length of 25.9 km.

Porongo is a village located in Andrés Ibáñez Province in Santa Cruz Department, Bolivia.

Pucará is a small town in Bolivia.

Puerto Busch is located in the province of Germán Busch, Santa Cruz Province, republic of Bolivia on the Paraguay River in eastern Bolivia. It is named in honor of General Germán Busch, who fought in the Chaco War.

Puerto Quijarro is a Bolivian city and an inland river port and situated on the Tamengo Canal in Bolivia, by the border with Brazil. It is part of the province of Germán Busch in the Santa Cruz Department. The Tamengo Canal connects it to the important Paraná-Paraguay Waterway. It is Bolivia's only waterway which leads to the ocean.

The Quizer River is a river of Bolivia.

Roboré is a town in eastern Bolivia.

San Carlos (Ichilo) is a small town in Bolivia.

San Ignacio de Velasco, is the capital of the José Miguel de Velasco Province and the San Ignacio de Velasco Municipality in the Santa Cruz Department of Bolivia.

San Ignacio de Velasco Municipality is the first municipal section of José Miguel de Velasco Province in Santa Cruz Department, Bolivia. Its capital is San Ignacio de Velasco.

San Jorge Lake is a lake in the Guarayos Province/Marbán Province, Beni Department, Bolivia. At an elevation of 160 m, its surface area is 68.6 km².

San Matías Integrated Management Natural Area is a protected area in Bolivia located in the Santa Cruz Department.

San Rafael de Velasco or San Rafael is the seat of the San Rafael Municipality in the José Miguel de Velasco Province, Santa Cruz Department, Bolivia. It is part of the Jesuit Missions of Chiquitos. In 1990 it was declared a World Heritage Site.

San Rafael Municipality is the third municipal section of the José Miguel de Velasco Province in the Santa Cruz Department, Bolivia. San Rafael de Velasco is the seat of the municipality. Its mission church is part of the World Heritage Site Jesuit Missions of Chiquitos.

Santa Rosa is a remote rural village in the Department of Santa Cruz, Bolivia. It lies to the North of the Santa Cruz/Cochabamba highway and on the Southern border of the Amboro National Park.

Taborga Lake is a lake in the Santa Cruz Department, Bolivia. At an elevation of 200 m, its surface area is 25.5 km².

Taquipirenda is a gas pipeline station in the Santa Cruz Department of Bolivia.

Tucavaca Valley Municipal Reserve is a protected area in Bolivia situated in the Santa Cruz Department, Chiquitos Province, Roboré Municipality. The reserve is located at an altitude between 200 m and 1250 m above sea level. It comprises the Santiago mountain range and the Tucavaca valley.

Vallegrande Municipality is the first municipal section of the Vallegrande Province in the Santa Cruz Department, Bolivia. Its capital is Vallegrande.

Laguna Volcán is a lake in the Florida Province of the Santa Cruz Department in Bolivia. Its surface area is 0.059 km².

Warnes is a town in Bolivia, named after Colonel Ignacio Warnes, a military leader in the South American war of independence. It is located 24 kilometers north of Santa Cruz de la Sierra.