
The Aztecs were a Mesoamerican culture that flourished in central Mexico in the post-classic period from 1300 to 1521. The Aztec peoples included different ethnic groups of central Mexico, particularly those groups who spoke the Nahuatl language and who dominated large parts of Mesoamerica from the 14th to the 16th centuries. Aztec culture was organized into city-states (altepetl), some of which joined to form alliances, political confederations, or empires. The Aztec Empire was a confederation of three city-states established in 1427: Tenochtitlan, city-state of the Mexica or Tenochca; Texcoco; and Tlacopan, previously part of the Tepanec empire, whose dominant power was Azcapotzalco. Although the term Aztecs is often narrowly restricted to the Mexica of Tenochtitlan, it is also broadly used to refer to Nahua polities or peoples of central Mexico in the prehispanic era, as well as the Spanish colonial era (1521–1821). The definitions of Aztec and Aztecs have long been the topic of scholarly discussion ever since German scientist Alexander von Humboldt established its common usage in the early nineteenth century.

Capacha is an archaeological site located about 6 kilometers northeast of the Colima Municipality, in Colima State, Mexico. This site is the heart of the ancient Mesoamerican Capacha Culture.

Chichimeca is the name that the Nahua peoples of Mexico generically applied to nomadic and semi-nomadic peoples who were established in present-day Bajio region of Mexico. Chichimeca carried the same sense as the Roman term "barbarian" to describe Germanic tribes. The name, with its pejorative sense, was adopted by the Spanish Empire. For the Spanish, in the words of scholar Charlotte M. Gradie, "the Chichimecas were a wild, nomadic people who lived north of the Valley of Mexico. They had no fixed dwelling places, lived by hunting, wore little clothes and fiercely resisted foreign intrusion into their territory, which happened to contain silver mines the Spanish wished to exploit." In spite of not having temples or idols, they practiced animal and human sacrifice, and they were feared for their expertise and brutality in war.

The Cochimí were the aboriginal inhabitants of the central part of the Baja California peninsula, from El Rosario in the north to San Javier in the south.

The Epi-Olmec culture was a cultural area in the central region of the present-day Mexican state of Veracruz. Concentrated in the Papaloapan River basin, a culture that existed during the Late Formative period, from roughly 300 BCE to roughly 250 CE. Epi-Olmec was a successor culture to the Olmec, hence the prefix "epi-" or "post-". Although Epi-Olmec did not attain the far-reaching achievements of that earlier culture, it did realize, with its sophisticated calendrics and writing system, a level of cultural complexity unknown to the Olmecs.

The Guachichil, Cuauchichil, or Quauhchichitl, are an Indigenous people of Mexico. Pre-contact, they occupied the most extensive territory of all the indigenous Chichimeca Nations tribes in pre-Columbian Central Mexico.

The Mixtecs, or Mixtecos, are indigenous Mesoamerican peoples of Mexico inhabiting the region known as La Mixteca of Oaxaca and Puebla as well as the state of Guerrero's Región Montañas, and Región Costa Chica, which covers parts of the Mexican states of Oaxaca, Guerrero and Puebla.

The Olmecs were the earliest known major Mesoamerican civilization. Following a progressive development in Soconusco, they occupied the tropical lowlands of the modern-day Mexican states of Veracruz and Tabasco. It has been speculated that the Olmecs derived in part from the neighboring Mokaya or Mixe–Zoque cultures.

The Preclassic period in Maya history stretches from the beginning of permanent village life c. 1000 BC until the advent of the Classic Period c. 250 AD, and is subdivided into Early, Middle, and Late. Major archaeological sites of this period include Nakbe, Uaxactun, Seibal, San Bartolo, Cival, and El Mirador.

The Toltec culture is a pre-Colombian Mesoamerican culture that ruled a state centered in Tula, Hidalgo, Mexico in the early post-classic period of Mesoamerican chronology. The later Aztec culture saw the Toltecs as their intellectual and cultural predecessors and described Toltec culture emanating from Tōllān [ˈtoːlːaːn] as the epitome of civilization; in the Nahuatl language the word Tōltēcatl [toːlˈteːkat͡ɬ] (singular) or Tōltēcah [toːlˈteːkaʔ] (plural) came to take on the meaning "artisan". The Aztec oral and pictographic tradition also described the history of the Toltec Empire, giving lists of rulers and their exploits.

The Zapotec civilization was an indigenous pre-Columbian civilization that flourished in the Valley of Oaxaca in Mesoamerica. Archaeological evidence shows that their culture originated at least 2,500 years ago. The Zapotec archaeological site at the ancient city of Monte Albán has monumental buildings, ball courts, magnificent tombs and grave goods, including finely worked gold jewelry. Monte Albán was one of the first major cities in Mesoamerica. It was the center of a Zapotec state that dominated much of the territory which today is known as the Mexican state of Oaxaca.