
Agent J is a fictional MIB agent in the film Men in Black, its sequels Men in Black II and Men in Black 3, and Men in Black: The Series. Jay is portrayed by Will Smith in the three films and voiced by Keith Diamond in the animated series.

Agent K is a fictional character in the Men in Black franchise. Kay is portrayed by Tommy Lee Jones in the three films and voiced by Ed O'Ross and Gregg Berger in the animated series. The film's trading card series and Men in Black: The Game give K's full name as Kevin Cunningham, a nod to Lowell Cunningham, the creator of the comic.

Daphne Blake is a fictional character in the Scooby-Doo franchise. Daphne, depicted as coming from a wealthy family, is noted for her orange hair, lavender heels, fashion sense, and her knack for getting into danger, hence the nickname "Danger Prone Daphne". She has appeared in more adaptations than the other characters, aside from Shaggy Rogers and Scooby-Doo.

The Bureau for Paranormal Research and Defense is a fictional organization in the comic book work of Mike Mignola, founded by the United States and United Kingdom governments, charged with researching the occult, paranormal and supernatural, and defending against their dangers. The B.P.R.D. originally appeared in the Hellboy comics and has since been a major part of its expanded universe.

The Challengers of the Unknown is a fictional group of adventurers appearing in comic books published by DC Comics. The quartet of adventurers explored paranormal occurrences while facing several fantastic menaces.

Velma Dinkley is a fictional character in the Scooby-Doo franchise. She is usually seen wearing a baggy orange turtleneck, a short red pleated skirt, knee socks, Mary Jane shoes, and a pair of black square glasses, which she frequently loses. She is seen as the "brains" of the group.

Frank the Pug is a fictional character from the Men in Black franchise, first seen in the 1997 film. He has also appeared in the 2002 sequel, 2019 spin-off, the animated series and the video game MIB: Alien Crisis. Within the films, Frank has the appearance of a normal pug dog, but he is actually an extraterrestrial in disguise. Frank is played in the first two films by a trained pug named Mushu, who was previously owned by Dylan and Caius, with Tim Blaney providing his voice in the films and the video game. In the animated series, the voice is provided by Eddie Barth.

Melinda Irene Gordon is the title character of the American paranormal television series Ghost Whisperer created by John Gray. Gordon was portrayed by American actress Jennifer Love Hewitt.

Hellboy is a fictional superhero created by writer-artist Mike Mignola. The character first appeared in San Diego Comic-Con Comics #2, and has since appeared in various eponymous miniseries, one-shots and intercompany crossovers. The character has been adapted into three live-action feature films. Two starring Ron Perlman in 2004 and 2008 in the title role, and one in 2019 which starred David Harbour, as well as two straight-to-DVD animated films, and three video games – Asylum Seeker, The Science of Evil, and as a playable character in Injustice 2.

Darwin Jones is a fictional scientist, a comic book character published by DC Comics. He first appeared in Strange Adventures #1, and was created by David V Reed and Paul Norris.

Frederick Herman Jones is a fictional character in the American animated series Scooby-Doo, about a quartet of teenage mystery solvers and their Great Dane companion, Scooby-Doo. He has been mostly voiced by Frank Welker since the character's inception in 1969.

Madame Xanadu is a comic book mystic published by DC Comics. The character is identified with Nimue, the sorceress from Arthurian mythology made popular by Sir Thomas Malory's Le Morte d'Arthur.

Janine Melnitz is a fictional character in the Ghostbusters series. She is the Ghostbusters' secretary, confidante, and occasionally, a ghostbuster herself. She was played by Annie Potts in both movies, and in The Real Ghostbusters she was voiced initially by Laura Summer, and later on the series by Kath Soucie. In Extreme Ghostbusters, she was voiced by Pat Musick. Potts returned to provide her appearance and voice to Janine in the 2009's Ghostbusters: The Video Game.

FBI Special Agent Fox William Mulder is a fictional character in the Fox science fiction-supernatural television series The X-Files, played by David Duchovny. Mulder's peers consider his theories on extraterrestrial activity as spooky and far-fetched. With his FBI partner Dana Scully, he works in the X-Files office, which is concerned with cases with particularly mysterious or possibly paranormal circumstances that were left unsolved and shelved by the FBI. Mulder was a main character for the first seven seasons, but was limited to a recurring character for the following two seasons. He returns as a main character for the tenth and eleventh seasons.

Norville "Shaggy" Rogers is a fictional character in the Scooby-Doo franchise. He is a cowardly slacker and the long-time best friend of his equally cowardly Great Dane, Scooby-Doo. Like Scooby-Doo, Shaggy is more interested in eating than solving mysteries.

Dana Katherine Scully is a fictional character in the Fox science fiction-supernatural television series The X-Files, played by Gillian Anderson. Scully is an FBI agent and a medical doctor (M.D.), partnered with fellow Special Agent Fox Mulder for the first seven and with John Doggett in the eighth and ninth seasons. In the television series, they work out of a cramped basement office at FBI headquarters in Washington, D.C. to investigate unsolved cases labeled "X-Files". In 2002, Scully left government employment, and in 2008 she began working as a surgeon in Our Lady of Sorrows, a private Catholic hospital – where she stayed for seven years, until rejoining the FBI. In contrast to Mulder's credulous "believer" character, Scully is the skeptic for the first seven seasons, choosing to base her beliefs on what science can prove. She later on becomes a "believer" after Mulder's abduction at the end of season seven.

The Second Life of Doctor Mirage is an 18-issue American comic book series co-created by writer/artist Bob Layton and illustrator Bernard Chang, and published by Valiant Comics. More than two million comics in the series have been sold since it was published from 1993–1995. The Second Life of Dr. Mirage has been translated into German, Italian, Spanish, Norwegian, Filipino, Chinese, and other languages.

Egon Spengler, PhD is a fictional character from the Ghostbusters franchise. He appears in the films Ghostbusters and Ghostbusters II, in the animated television series The Real Ghostbusters and Extreme Ghostbusters, in the video games Ghostbusters: The Video Game and Beeline's Ghostbusters. Spengler was portrayed by Harold Ramis in the films and voiced by him in Ghostbusters: The Video Game and Lego Dimensions, and voiced by Maurice LaMarche in the cartoon series. He is a member of the Ghostbusters and one of the three doctors of parapsychology, along with Dr. Peter Venkman and Dr. Ray Stantz.

Raymond Stantz, PhD is a fictional character from the Ghostbusters franchise. He appears in the films Ghostbusters (1984), Ghostbusters II (1989), Casper and Ghostbusters: Afterlife (2021), the animated television series The Real Ghostbusters and Extreme Ghostbusters, and the video games Beeline's Ghostbusters and Ghostbusters: The Video Game. He was portrayed by Dan Aykroyd in all four live action films, and voiced by Frank Welker in the animated series. He is a member of the Ghostbusters and one of the three doctors of parapsychology, along with Dr. Peter Venkman and Dr. Egon Spengler.

Tucker's Witch is a comedy-detective series that aired on CBS television from October 6, 1982, to November 10, 1982, and again sporadically from March 31 to June 9, 1983. It starred Tim Matheson and Catherine Hicks as a charming married couple, Rick and Amanda Tucker, who own and operate their private detective agency in Laurel Canyon in Los Angeles. Amanda possesses psychic powers, which is an asset in solving cases but also tends to get the pair into various troubles.

Peter Venkman, Ph.D., is a fictional character from the Ghostbusters franchise. He appears in the films Ghostbusters, Ghostbusters II and Ghostbusters: Afterlife and in the animated television series The Real Ghostbusters. In both live action films, he was portrayed by Bill Murray, and was voiced in the animated series first by Lorenzo Music and then by Dave Coulier. He is a parapsychologist and the leader of the Ghostbusters.

Dean Winchester is one of the two protagonists from the American drama television series Supernatural. He is portrayed primarily by Jensen Ackles. Other versions of the character having been portrayed by Hunter Brochu (toddler), Ridge Canipe (child), Nicolai Lawton-Giustra (pre-teen), Brock Kelly and Dylan Everett (teen), and Chad Everett (elderly).

Samuel Winchester is a fictional character and one of the protagonists of the American drama television series Supernatural along with his older brother, Dean. He is portrayed primarily by Jared Padalecki.

Wynonna Earp is a weird West comic book miniseries created and owned by Beau Smith. The series was initially published by Image Comics, and from 2003 by IDW Publishing.

Dr. Winston Zeddemore is a fictional character appearing in the Ghostbusters films, TV series, and video games. He was played by Ernie Hudson in both movies and was voiced by Arsenio Hall in the first two seasons of The Real Ghostbusters. Buster Jones provided Winston's voice in the remaining seasons, and he reprised the role in a cameo on Extreme Ghostbusters. Hudson returned to provide his appearance and voice to Zeddemore in 2009's Ghostbusters: The Video Game.