Doctor EggmanW
Doctor Eggman

Doctor Ivo "Eggman" Robotnik is a fictional character and the main antagonist of Sega's Sonic the Hedgehog series. Eggman was created and designed by Naoto Ohshima as part of many design choices for Sega's new mascot. After the creation of Sonic the Hedgehog, Ohshima chose to use his previous egg-shaped character to create the antagonist of the 1991 video game Sonic the Hedgehog, making him the archenemy of the series' eponymous main character.

Doctor Neo CortexW
Doctor Neo Cortex

Doctor Neo Cortex is a fictional character and the main antagonist of the Crash Bandicoot video game series. He has appeared in every mainline game in the series as Crash Bandicoot's archenemy, as well as a playable character in several spin-off titles. Cortex is an egomaniacal mad scientist who seeks to achieve world domination with the use of the Evolvo-Ray, a machine capable of creating genetically enhanced soldiers from ordinary animals. Crash was one such subject and was intended by Cortex to be the general of his army, but was rejected as a failure preceding his escape and subsequent thwarting of Cortex's plot. As a result, Cortex is determined to eliminate Crash as an obstacle in his path to world domination. Cortex was created by Naughty Dog founders Andy Gavin and Jason Rubin, and was originally designed by Charles Zembillas. Voice actors who have portrayed Cortex include Brendan O'Brien, Clancy Brown and Lex Lang. Cortex has been positively received by reviewers, with much of the praise going to Brown's and Lang's vocal performances as well as the character's portrayal in Crash Twinsanity.

Elexis SinclaireW
Elexis Sinclaire

Elexis Sinclaire is a fictional character in the SiN first-person shooter video game series by Ritual Entertainment. Elexis is the main antagonist character in the cyberpunk-themed SiN series, where she is a mysterious, wealthy and powerful mad scientist who is secretly engaged in organized crime and planning to make a radical artificial evolutionary advance to the human race, and enemy of the protagonist character, private security force commander John R. Blade.

F.A.N.G.W
F.A.N.G.

F.A.N.G. , pronounced as "Fong", is a fictional character in Capcom's Street Fighter series. He made his first appearance in Street Fighter V as one of sixteen playable characters at the game's launch in 2016. Within series lore, F.A.N.G. is an assassin who uses poison techniques to complement his fighting style and the self-proclaimed second-in-command of Shadaloo, as he considers himself ranking only below M. Bison in the hierarchy. While the character is generally well received by video game journalists due to his eccentric character design and unconventional gameplay, F.A.N.G. is known for being one of the most infrequently selected characters in Street Fighter V, both in casual and professional play. This is because F.A.N.G. is often perceived to be one of the game's most underpowered characters, and is thus not an ideal choice in player versus player matches.

FawfulW
Fawful

Fawful, known in Japan as Gerakobits , is a fictional character appearing in the Mario & Luigi series of role-playing video games developed by AlphaDream. The character is considered to be "insane," and served as the secondary antagonist of Superstar Saga and the main antagonist of Bowser's Inside Story.

Kefka PalazzoW
Kefka Palazzo

Kefka Palazzo is a character in the Final Fantasy series of video games. Originally designed by Yoshitaka Amano, he appears in the 6th installment of the series - Final Fantasy VI. First introduced as the court jester and army general under Emperor Gestahl, throughout the game he reveals himself to be a nihilistic psychopath after setting in motion events leading to the Apocalypse and pronouncing himself the God of Magic. From that point he acts as the game's primary antagonist.

Fallout (video game)W
Fallout (video game)

Fallout: A Post Nuclear Role Playing Game is an open-world turn-based role-playing video game developed and published by Interplay Productions in 1997. The game has a post-apocalyptic and retro-futuristic setting, taking place in the mid-22nd century decades after a global nuclear war in an alternate history timeline. The protagonist of Fallout is an inhabitant of a Vault, part of a network of long-term nuclear shelters, who is forced to venture out into the wastes to find a replacement Water Chip and save their fellow Vault inhabitants.

Team Fortress 2W
Team Fortress 2

Team Fortress 2 is a multiplayer first-person shooter game developed and published by Valve. It is the sequel to the 1996 Team Fortress mod for Quake and its 1999 remake, Team Fortress Classic. It was released in October 2007 as part of The Orange Box video game bundle for Windows and Xbox 360. A PlayStation 3 version followed in December 2007 when The Orange Box was ported to the system. Later in development, the game was released as a standalone title for Windows in April 2008, and was updated to support Mac OS X in June 2010 and Linux in February 2013. It is distributed online through Valve's digital retailer Steam, with Electronic Arts handling all physical and console ports of the game.

Dr. WilyW
Dr. Wily

Doctor Albert W. Wily , known simply as Doctor Wily , is a video game character and the main antagonist of the original Mega Man series, as well as Mega Man's archenemy. He appeared in the first Mega Man video game and later in promotions and other media related to the series. In Japanese, he is voiced by Takeshi Aono in all appearances except Mega Man: The Power Battle and its sequel, as well as Mega Man: Upon a Star, where he instead was voiced by Kenichi-Ogata; in English, the character is voiced by Dean Galloway, Douglas Kendall, Keith Silverstein, Ian James Corlett and Scott McNeil voicing the character in Mega Man Powered Up, Mega Man 8, Mega Man 11, Captain N: The Game Master, and the animated series, respectively.