
The Basement Collection is a compilation of Edmund McMillen's Flash games released on August 31, 2012. The games were remade with added features and music tracks.

The Binding of Isaac is a roguelike video game designed by independent developers Edmund McMillen and Florian Himsl. It was released in 2011 for Microsoft Windows, then ported to OS X, and Linux. The game's title and plot are inspired by the Biblical story of the Binding of Isaac. In the game, Isaac's mother receives a message from God demanding the life of her son as proof of her faith, and Isaac, fearing for his life, flees into the monster-filled basement of their home where he must fight to survive. Players control Isaac or one of seven other unlockable characters through a procedurally generated dungeon in a roguelike manner, fashioned after those of The Legend of Zelda, defeating monsters in real-time combat while collecting items and power-ups to defeat bosses and eventually Isaac's mother.

Cadence of Hyrule: Crypt of the NecroDancer Featuring The Legend of Zelda is a rhythm game developed by Brace Yourself Games and published by Nintendo. The game is a crossover of Crypt of the NecroDancer with The Legend of Zelda, combining the rhythm-based movement and fighting mechanics with elements reminiscent of earlier games in the Zelda franchise. The game was released for the Nintendo Switch on June 13, 2019.

Canabalt is a 2009 side-scrolling endless runner video game designed by Adam Saltsman for the Experimental Gameplay Project. It has been released on iOS, Commodore 64, PlayStation Portable, Android, Ouya and various Flash based online gaming websites, such as Kongregate.

Cave Story 3D is a Metroidvania platform-adventure game developed by Nicalis and published by Nippon Ichi Software. It was released on November 8, 2011 for the Nintendo 3DS. A remake of the indie video game Cave Story developed by Daisuke "Pixel" Amaya, the entire game was redesigned with 2.5D graphics, with the ability to switch between 2D and 3D characters and enemies, and the soundtrack was remixed by Danny Baranowsky. The game received positive reviews from critics, who praised its design as remaining exemplary, although they criticized its similarities to the original and the loss of Curly Brace and Boss Rush mode, saying it was a poor value compared to other versions.

Crypt of the NecroDancer is a roguelike rhythm video game developed and published by Canadian independent game studio Brace Yourself Games. The game takes fundamental elements of a roguelike dungeon exploration game and adds a beat-matching rhythm game set to an original soundtrack written by Danny Baranowsky. The player's actions are most effective when moving the character set to the beat of the current song and are impaired when they miss a beat, so it is necessary to learn the rhythmic patterns that the various creatures follow. The mixed-genre game includes the ability to import custom music, and the option to use a dance pad instead of traditional controllers or the keyboard. The game was released for Microsoft Windows, OS X, and Linux in April 2015, being co-published by Klei Entertainment, for the PlayStation 4 and Vita in February 2016, for the Xbox One in February 2017, and for Nintendo Switch in February 2018. Crypt of the NecroDancer Pocket Edition, developed for iOS, was released in June 2016.

Desktop Dungeons is a single-player roguelike-like puzzle video game developed and published by QCF Design. Released in November 2013, the game underwent a lengthy public beta phase, during which it was available to customers who pre-ordered the game. In the game, players navigate a dungeon filled with monsters before battling a final dungeon boss. The game has qualities of a puzzle as players must find the best methods to use items, spells, and upgrades to reach the final boss without losing too much of their character's health. Desktop Dungeons has been compared to a roguelike but with condensed gameplay. Desktop Dungeons received an award for Excellence in Design at the 2011 Independent Games Festival. The game is available for Windows, Macintosh, Linux, iOS and Android.

Super Meat Boy is a 2010 platform game designed by Edmund McMillen and Tommy Refenes under the collective name of "Team Meat". It was self-published as the successor to Meat Boy, a 2008 flash game designed by McMillen and Jonathan McEntee. In the game, the player controls Meat Boy, a red, cube-shaped character, as he attempts to rescue his girlfriend, Bandage Girl, from the game's antagonist Dr. Fetus. The gameplay is characterized by fine control and split-second timing, as the player runs and jumps through over 300 hazardous levels while avoiding obstacles. The game also supports the creation of player-created levels. Super Meat Boy was first released on the Xbox 360 through Xbox Live Arcade in October 2010, and was later ported to Microsoft Windows, OS X, Linux, PlayStation 4, PlayStation Vita, Wii U, and the Nintendo Switch.