
3-D Body Adventure is a 1994 educational video game developed by Knowledge Adventure and published by Levande Böcker i Norden for DOS, Mac OS, and Windows.

A.D.A.M. Life's Greatest Mysteries is an educational interactive CD-ROM game. The title aims to debunk myths about the human body, mind, sickness, and other topics.

A.D.A.M. The Inside Story is a 1995 educational interactive CD-ROM. It was one in a series of titles made in collaboration between Columbia/HCA Healthcare Corporation and A.D.A.M. Software, alongside titles such as A.D.A.M. Life's Greatest Mysteries and A.D.A.M. Nine Month Miracle.

Astronomica: The Quest for the Edge of the Universe is an educational game made by Hyper-Quest, Inc. in 1994 for Macintosh and Windows 3.x. The game developers purposely made the game's main character a girl, explaining "Younger girls are often left out of multimedia games, so we made the main character in Astronomica a girl".

Atom is an action game published by Tandy in 1983 for the TRS-80 Color Computer. The game educates the player about the elements of the periodic table from hydrogen through xenon.

Buzz Aldrin's Race Into Space, frequently abbreviated BARIS, is a 1993 space simulation strategy game for MS-DOS. The player takes the role of Administrator of NASA or head of the Soviet space program with the ultimate goal of being the first side to conduct a successful manned Moon landing. It was developed by Strategic Visions and published by Interplay Productions as a computer version of LIFTOFF!, a 1989 board game developed by Fritz Bronner. BARIS was re-released in 1994 on CD-ROM, incorporating the earlier updates to the floppy disk version, a few new updates, improved video of the mission launches, and new multiplayer modes.

Captain Novolin is a 1992 educational platform video game, developed by Sculptured Software and published by Raya Systems for the Super Nintendo Entertainment System. Starring the eponymous superhero with type 1 diabetes, the game sees the player control Captain Novolin on a quest to save the mayor of Pineville from the supervillain Blubberman. It is a part of educational video game series from Raya that also includes Rex Ronan: Experimental Surgeon, Packy and Marlon, and Bronkie the Bronchiasaurus.

Designasaurus an educational game created by Ezra Sidran and published by Britannica Software. It was released for Amiga, Apple II, Apple IIgs, Commodore 64, and MS-DOS. The game is about creating a custom dinosaur and helping it survive. It is divided into three activities: "Walk-a-Dinosaur", "Build-a-Dinosaur" and "Print-a-Dinosaur".

Genomics Digital Lab (GDL) is a browser-based series of educational games, simulations, and animations created by Spongelab Interactive. It is designed to teach high school students about biology including photosynthesis, respiration, transcription, and translation. Genomics Digital Lab was released in 2009 and is available for purchase at home or school, or as a free 7-day trial.

Super Solvers: Gizmos & Gadgets is an educational science video game designed by The Learning Company. It is intended to teach children between the ages of 7 and 12 introductory mechanics, namely simple machines, magnets, basic electronics, and forms of energy. The original game is compatible with computers running DOS 3.3 or higher and a later CD release added Windows 95 and Macintosh compatibility. A popular game through 1997, The Learning Company, then incorporated with Broderbund, discontinued Gizmos & Gadgets in 1998. Riverdeep eventually obtained the rights and re-released it in some of the "Adventure Workshop" collections.

History of Biology is a browser based scavenger hunt style educational game created by Spongelab Interactive. It is designed to teach high school students and general interest groups about the history of biology

Mia's Science Adventure: Romaine's New Hat is the second title of the Mia's Big Adventure Collection software series created by Kutoka Interactive. Released in 2000 in Canada and the United States, the game teaches sciences to children between 6 and 10 years old.

MoonBaseOne is an educational video game. It was developed by American company WeCreateGames.com, and was published by Federation of Galaxy Explorers. Posted for free download on July 15, 2007, MoonBaseOne was developed as an educational tool to be used at FOGE summer camps to teach kids about space.
NanoMission is a serious game series made by PlayGen for Wellcome Trust and FEI to teach the player about the world of nanomedicine. There are four downloadable modules available, each teaching different concepts related to nanotechnology. The gameplay varies greatly between the different modules in the series offering a wide variety of gameplay.

Odell Down Under is a 1995 game for Microsoft Windows and Classic Mac OS that takes place in the Great Barrier Reef. It is the sequel to Odell Lake.

Quarky & Quaysoo's Turbo Science is an educational computer game developed by Jeff Tunnell Productions and published by Sierra On-Line for MS-DOS in early 1992. It was designed to teach scientific concepts to children.

The Sacred Mirror of Kofun is a 1996 puzzle video game/multimedia encyclopedia co-produced by Jean-Michel Cousteau with the cooperation of the National Center of Cinematography and the moving image and the French Ministry of Economy, Finances and Industry. It features full motion video sequences and actual underwater footage, the first game to do so.

Science Seekers is a trilogy of science-related educational video games for the Windows and Macintosh platforms, developed and published by Tom Snyder Productions. The American Museum of Natural History collaborated in the series' development and got a grant from NASA. The series consists of Science Seekers: Hidden in Rocks, Science Seekers: Endangered Species and Science Seekers: Safe Water.

Widget Workshop: A Mad Scientist's Laboratory is a hands-on science kit, for use on the computer and off. It was released in 1995 and is one of the more obscure Maxis products. It was designed by Lauren Elliott, co-author of the Where in the World is Carmen SanDiego game series.