
The secretary of defense (SecDef) is the leader and chief executive officer of the United States Department of Defense, the executive department of the Armed Forces of the U.S. The secretary of defense's position of command and authority over the U.S. military is second only to that of the president. This position corresponds to what is generally known as a defense minister in many other countries. The secretary of defense is appointed by the president with the advice and consent of the Senate, and is by custom a member of the Cabinet and by law a member of the National Security Council.

Leslie Aspin Jr. was a United States Representative from 1971 to 1993, and the United States Secretary of Defense under President Bill Clinton from January 21, 1993 to February 3, 1994. In Congress, Aspin had a reputation as an intellectual who took a middle-of-the-road position on controversial issues. He supported the Reagan administration regarding the MX missile and aid to the Nicaraguan Contras, but he opposed the B-2 bomber and the Strategic Defense Initiative. He played a major role in convincing the House to support the January 1991 resolution supporting the use of force by President G.H.W. Bush against Iraq, after it invaded Kuwait. As Secretary of Defense, he faced complex social issues, such as the roles of homosexuals in uniform, and of women in combat, as well as major decisions regarding the use of military force in Somalia, Bosnia, and Haiti. He proposed budget cuts and restructuring of forces as part of the downsizing of the military after the end of the Cold War. The deaths of U.S. soldiers in Somalia because of inadequate military support led to his resignation.

Harold Brown was an American nuclear physicist who served as United States Secretary of Defense from 1977 to 1981, under President Jimmy Carter. Previously, in the John F. Kennedy and Lyndon B. Johnson administrations, he held the posts of Director of Defense Research and Engineering (1961–1965) and United States Secretary of the Air Force (1965–1969).
Frank Charles Carlucci III was an American politician and diplomat who served as the United States Secretary of Defense from 1987 to 1989 in the administration of President Ronald Reagan.

Ashton Baldwin Carter is an American public policy professor who served as the 25th secretary of defense from February 2015 to January 2017. He is currently Director of the Belfer Center for Science & International Affairs at Harvard Kennedy School.

Richard Bruce Cheney is an American politician and businessman who served as the 46th vice president of the United States from 2001 to 2009. He has been cited as the most powerful vice president in American history. He is also one of the most unpopular politicians in the history of the US, holding an approval rating of just 13% at the time of leaving office.

Clark McAdams Clifford was an American lawyer who served as an important political adviser to Democratic presidents Harry S. Truman, John F. Kennedy, Lyndon B. Johnson, and Jimmy Carter. His official government positions were White House Counsel (1946–1950), Chairman of the President's Intelligence Advisory Board (1963–1968), and Secretary of Defense (1968–1969); Clifford was also influential in his role as an unofficial, informal presidential adviser in various issues. A successful Washington lawyer, he was known for his elite clientele, charming manners, and impeccable suits.

William Sebastian Cohen is an American politician, lawyer and author from the U.S. state of Maine. A Republican, Cohen served as both a member of the United States House of Representatives (1973–1979) and Senate (1979–1997), and as Secretary of Defense (1997–2001) under Democratic President Bill Clinton.

Mark Thomas Esper is the 27th and current United States secretary of defense, and a former U.S. Army officer and defense contractor lobbyist before his appointment. He previously served as the 23rd United States secretary of the Army from 2017 to 2019.

James Vincent Forrestal was the last Cabinet-level United States Secretary of the Navy and the first United States Secretary of Defense.

Robert Michael Gates is an American intelligence analyst, and university president who served as the 22nd United States Secretary of Defense from 2006 to 2011. He was originally appointed by President George W. Bush and was retained for service by President Barack Obama. Gates began his career serving as an officer in the United States Air Force but was quickly recruited by the Central Intelligence Agency (CIA). Gates served for 26 years in the CIA and the National Security Council, and was Director of Central Intelligence under President George H. W. Bush. After leaving the CIA, Gates became president of Texas A&M University and was a member of several corporate boards. Gates served as a member of the Iraq Study Group, the bipartisan commission co-chaired by James A. Baker III and Lee H. Hamilton, that studied the lessons of the Iraq War.

Thomas Sovereign Gates Jr. was an American politician and diplomat who served as Secretary of Defense from 1959 to 1961 and Secretary of the Navy from 1957 to 1959, both under President Dwight D. Eisenhower. During his tenure as Secretary of Defense, he established a task force to set nuclear target priorities. He also authorized U-2 reconnaissance flights, including the flight of Francis Gary Powers.

Charles Timothy Hagel is an American military veteran and former politician who served as a United States Senator from Nebraska from 1997 to 2009 and as the 24th United States Secretary of Defense from 2013 to 2015 in the Obama administration.

Louis Arthur Johnson was an American politician and attorney who served as the second United States Secretary of Defense from 1949 to 1950. He was the Assistant Secretary of War from 1937 to 1940 and the 15th national commander of The American Legion, from 1932 to 1933.
Melvin Robert Laird was an American politician, writer and statesman. He was a U.S. congressman from Wisconsin from 1953 to 1969 before serving as Secretary of Defense from 1969 to 1973 under President Richard Nixon. Laird was instrumental in forming the administration's policy of withdrawing U.S. soldiers from the Vietnam War; he coined the expression "Vietnamization," referring to the process of transferring more responsibility for combat to the South Vietnamese forces. First elected in 1952, Laird was the last surviving Representative elected to the 83rd Congress at the time of his death.

Robert Abercrombie Lovett was the fourth United States Secretary of Defense, having been promoted to this position from Deputy Secretary of Defense. He served in the cabinet of President Harry S. Truman from 1951 to 1953 and in this capacity, directed the Korean War. As Under Secretary of State, he handled most of the tasks of the State Department while George C. Marshall was Secretary.

General of the Army George Catlett Marshall Jr. was an American soldier and statesman. He rose through the United States Army to become Chief of Staff under presidents Franklin D. Roosevelt and Harry S. Truman, then served as Secretary of State and Secretary of Defense under Truman. Winston Churchill lauded Marshall as the "organizer of victory" for his leadership of the Allied victory in World War II. Roosevelt passed over Marshall as allied commander in the invasion of France in favor of Dwight D. Eisenhower. After the war, he spent a frustrating year trying and failing to avoid the impending civil war in China. As Secretary of State, Marshall advocated a significant U.S. economic and political commitment to post-war European recovery, including the Marshall Plan that bore his name. In recognition of this work, he was awarded the Nobel Peace Prize in 1953.

James Norman Mattis is a retired United States Marine Corps general who served as the 26th US secretary of defense from January 2017 through January 2019. During his 44 years in the Marine Corps, he commanded forces in the Persian Gulf War, the War in Afghanistan, and the Iraq War.

Neil Hosler McElroy was United States Secretary of Defense from 1957 to 1959 under President Eisenhower. He had been president of Procter & Gamble.

Robert Strange McNamara was an American business executive and the eighth United States Secretary of Defense, serving from 1961 to 1968 under Presidents John F. Kennedy and Lyndon B. Johnson. He played a major role in escalating the United States' involvement in the Vietnam War. McNamara was responsible for the institution of systems analysis in public policy, which developed into the discipline known today as policy analysis.

Leon Edward Panetta is an American politician who has served in several different public office positions, including the Secretary of Defense, Director of the CIA, White House Chief of Staff, Director of the Office of Management and Budget, and as a U.S. Representative from California. A Democrat, Panetta was a member of the United States House of Representatives from 1977 to 1993, served as Director of the Office of Management and Budget from 1993 to 1994, and as President Bill Clinton's Chief of Staff from 1994 to 1997. He co-founded the Panetta Institute for Public Policy and served as a Distinguished Scholar to Chancellor Charles B. Reed of the California State University System and as a professor of public policy at Santa Clara University.

William James Perry is an American mathematician, engineer, businessman, and civil servant who was the United States Secretary of Defense from February 3, 1994, to January 23, 1997, under President Bill Clinton. He also served as Deputy Secretary of Defense (1993–1994) and Under Secretary of Defense for Research and Engineering (1977–1981).

Elliot Lee Richardson was an American lawyer and public servant who was a member of the cabinet of Presidents Richard Nixon and Gerald Ford. As U.S. Attorney General, he was a prominent figure in the Watergate Scandal, and resigned rather than obey President Nixon's order to fire special prosecutor Archibald Cox.

Donald Henry Rumsfeld is an American former politician. Rumsfeld served as Secretary of Defense from 1975 to 1977 under Gerald Ford, and again from January 2001 to December 2006 under George W. Bush. He is both the youngest and the second-oldest person to have served as Secretary of Defense. Additionally, Rumsfeld was a three-term U.S. Congressman from Illinois (1963–69), director of the Office of Economic Opportunity (1969–70), counsellor to the president (1969–73), the United States Permanent Representative to NATO (1973–74), and White House Chief of Staff (1974–75). Between his terms as Secretary of Defense, he served as the CEO and chairman of several companies.

James Rodney Schlesinger was an American economist and public servant who was best known for serving as Secretary of Defense from 1973 to 1975 under Presidents Richard Nixon and Gerald Ford. Prior to becoming Secretary of Defense, he served as Chair of Atomic Energy Commission (AEC) from 1971 to 1973, and as CIA Director for a few months in 1973. He became America's first Secretary of Energy under Jimmy Carter in 1977, serving until 1979.

Caspar Willard "Cap" Weinberger was an American politician and businessman. As a prominent Republican, he served in a variety of state and federal positions for three decades, including Chairman of the California Republican Party, 1962–68. Most notably he was Secretary of Defense under President Ronald Reagan from 1981 to 1987.

Charles Erwin Wilson was an American engineer and businessman who served as United States Secretary of Defense from 1953 to 1957 under President Dwight D. Eisenhower. Known as "Engine Charlie", he was previously the president and chief executive officer of General Motors. In the wake of the Korean War, he cut the defense budget significantly.