
Marta Carcana is a former Adjutant General of the Puerto Rico National Guard, serving during the administration of Puerto Rican governor Alejandro Garcia Padilla from 2015 to 2017. She is the first woman to hold that billet.

Brigadier General David A. Carrión Baralt is a former Adjutant General of the Puerto Rico National Guard during the administration of Puerto Rico Governor Aníbal Acevedo Vilá from 2004-2008.

Major General Carlos Fernando Chardón also referred to as "Fernando Chardón", was the Secretary of State of Puerto Rico from 1969 to 1973 and the Puerto Rico Adjutant General from 1973 to 1975.

Major General Juan César Cordero Dávila, was the commanding officer of the 65th Infantry Regiment during the Korean War, rising to become one of the highest ranking ethnic officers in the United States Army.

Carlos Del Castillo is a scientist who, in 2004, became the recipient of the Presidential Early Career Award for Scientists and Engineers (PECASE) award, the highest honor bestowed by the United States government on scientists and engineers beginning their independent careers. Del Castillo was the Program Scientist for the Ocean Biology and Biogeochemistry Program at NASA Headquarters, in Washington, D.C..
Major General Emilio Díaz Colón, is a former United States National Guard officer who served as the Adjutant General of the Puerto Rican National Guard. In 2011, he became the first member of the PRNG to be named Superintendent of the Puerto Rico Police Department.

Major General Luis Raul Esteves was the first Puerto Rican and the first American citizen of Hispanic heritage to graduate from the United States Military Academy, and the founder of the Puerto Rico National Guard. Of his West Point class, that included Dwight Eisenhower, Omar Bradley, Joseph McNarney, James Van Fleet and George E. Stratemeyer, Esteves was the first to achieve the rank of General.

Brigadier General Mihiel "Mike" Gilormini Pacheco, was a United States Air Force officer who served in the Royal Air Force and in the United States Army Air Forces during World War II. He was the recipient of the Silver Star, the Air Medal with four clusters and the Distinguished Flying Cross 5 times. He was also a co-founder of the Puerto Rico Air National Guard.
Epifanio "Epi" Jiménez Cruz in Carolina, Puerto Rico is a Puerto Rican politician who held many occupations in the New Progressive Party and was elected to a seat at 40th district in the Puerto Rico House of Representatives. Served as an officer in the Army National Guard of Puerto Rico.

Brigadier General Antonio Maldonado was an officer of the United States Air Force, who in 1967 became the youngest pilot and Aircraft Commander of a B-52 Stratofortress nuclear bomber. He served as Chief, U.S. Office of Defense Cooperation, Madrid, Spain. He was the senior Department of Defense representative to Spain and senior advisor to the US Ambassador to Spain. During the Persian Gulf War in 1991 he coordinated the overall US offensive operations from Spain.

William "Willie" Miranda Marín was the mayor of Caguas, Puerto Rico from 1997 until his death in 2010.

Juan José Medina Lamela is the 19th Puerto Rico Adjutant General, and the commanding officer of the Puerto Rico National Guard. Medina was born in Quebradillas, Puerto Rico, was a Boy Scout of the troop 92 of Quebradillas and currently held the rank of brigadier general.

Lieutenant Colonel José Antonio Muñiz was a United States Air Force officer who during World War II served in the United States Army Air Forces. He co-founded the Puerto Rico Air National Guard together with then-Colonels Alberto A. Nido and Mihiel Gilormini. In 1963, the Air National Guard Base, at the San Juan International Airport in Puerto Rico, was renamed "Muñiz Air National Guard Base" in his honor.

William A. Navas Jr. is a retired United States Army Major General who served as the Director of the Army National Guard. He is also the first Puerto Rican to be named an Assistant Secretary of the Navy.

Brigadier General Alberto A. Nido is a former United States Air Force officer who during World War II served in the Royal Canadian Air Force, the British Royal Air Force and in the United States Army Air Forces. He was also the co-founder of the Puerto Rico Air National Guard.

Brigadier General Rafael O'Ferrall is an Army National Guard officer who is the Deputy Commanding General for the Joint Task Force at Guantanamo Bay, Cuba and the Assistant Adjutant General (Army) and Deputy Commanding General of the Joint Force Headquarters at San Juan, Puerto Rico.

Orlando Ortiz Chevres is a Puerto Rican politician and the current mayor of Naranjito. Ortiz is affiliated with the New Progressive Party (PNP) and has served as mayor since 2009. He obtained a masters in administration and human resources from the Interamerican University of Puerto Rico. Ortiz is also serves in the Puerto Rico National Guard.

Brigadier General José M. Portela (Ret.),, is a retired officer of the United States Air Force who recently retired from the position of Assistant Adjutant General for Air, which he held while also serving as commander of the Puerto Rico Air National Guard. In 1972, Portela became the youngest C-141 Starlifter aircraft commander and captain at age 22. Portela is also the only reservist ever to serve as director of mobility forces for Bosnia. He is also the first native of Puerto Rico to hold the rank of Brigadier General in the United States Air Force Reserve.

José J. Reyes is the 22nd Puerto Rico Adjutant General, and the commanding officer of the Puerto Rico National Guard.

Isabelo Rivera Negrón was the 21st Puerto Rico Adjutant General, and the commanding officer of the Puerto Rico National Guard.

A mass shooting occurred at Fort Lauderdale–Hollywood International Airport in Broward County, Florida, United States, on January 6, 2017, near the baggage claim in Terminal 2. Five people were killed while six others were injured in the shooting. About 36 people sustained injuries in the ensuing panic. Esteban Santiago-Ruiz, who committed the shooting, was taken into custody within 90 seconds after he started shooting, surrendering to responding sheriff's deputies. He was later diagnosed with schizophrenia and pleaded guilty.

Colonel Antulio Segarra, was a United States Army officer who in 1943 became the first Puerto Rican in history to command a Regular Army Regiment. Segarra served as Military Aide to the Military Governor of Puerto Rico Theodore Roosevelt, Jr. and during World War II commanded the 65th Infantry Regiment.

Antonio J. Vicens-Gonzalez was the 18th Adjutant General of the Puerto Rico National Guard from January 2, 2009 to December 2012. The Adjutant General is the Commander of the Puerto Rico National Guard. As the Adjutant General he was also the Senior Military Advisor to the Governor of Puerto Rico and oversees both State and Federal Missions of the PR National Guard. He provides effective leadership and management in the implementation of all programs and policies affecting more than 10,500 citizen-soldiers and airmen, and civilian employees of the three components of the PR National Guard: Army National Guard, Air National Guard and Puerto Rico State Guard. MG Vicens holds a B.B.A-Management Degree from the University of Puerto Rico.