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Sir Paul Boffa, OBE was a Maltese prime minister (1947–50) who took office after self-rule was reinstated by the British colonial authority following the end of World War II.

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Sir Maurus Caruana, O.S.B., K.G.C., K.B.E., was a Maltese Benedictine monk who served as the Bishop of Malta and the Titular Archbishop of Rhodes.

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Sir Adrian "Adriano" Dingli was Chief Justice of Malta.

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Emanuele Luigi Galizia was a Maltese architect and civil engineer, who designed many public buildings and several churches. He is regarded as "the principal Maltese architect throughout the second half of the nineteenth century".

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Sir Michael Count Gonzi, KBE, was Roman Catholic Archbishop of Malta from 1944 until 1976. He had been enthroned as Bishop of Malta in December 1943, and was consecrated as the first Archbishop of Malta in 1944. He had also been Bishop of Gozo and an elected Labour Senator in the Malta Legislative Assembly.

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Sir Anthony Joseph Mamo, was the first President of Malta and previously served as the last Governor-General of the State of Malta before the country became a republic. He was also the first Maltese citizen to be appointed Governor-General, and before independence, briefly served as acting Governor.

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Sir Ugo Pasquale Mifsud was a Maltese politician, the 3rd Prime Minister of Malta under British home rule, and the first to serve a full term in power. He held office from 1924 to 1927 and from 1932 to 1933. He was a member of the Nationalist Party and the Maltese Italian community.

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Count Sir Luigi Preziosi was a Maltese politician and a doctor who specialized in ophthalmology. He was mostly known for devising an original operation for the treatment of glaucoma in 1924, which remained in use for many decades. He was born in the village of Sliema, Malta on 29 July 1888, the second son of the seventh Count Preziosi of Malta. He graduated in the Royal University of Malta in 1907 and subsequently specialised in ophthalmology in Oxford in 1920.

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Gerald Paul Joseph Cajetan Carmel Antony Martin Strickland, 6th Count della Catena, 1st Baron Strickland, was a Maltese and British politician and peer, who served as Prime Minister of Malta, Governor of the Leeward Islands, Governor of Tasmania, Governor of Western Australia and Governor of New South Wales, in addition to sitting successively in the House of Commons and House of Lords in the Parliament of the United Kingdom.

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Sir Themistocles "Temi" Zammit was a Maltese archaeologist and historian, professor of chemistry, medical doctor, researcher and writer. He served as Rector (1920–26) of the Royal University of Malta and first Director of the National Museum of Archaeology in his naive city, Valletta.