
In the Philippines, the Autonomous Region in Muslim Mindanao (ARMM) was the only autonomous region ; as such it is the sole region with a regional government as prescribed by the Constitution of the Philippines. In 2001, Republic Act No. 9054 was passed for the expansion of the ARMM to include the areas which initially rejected inclusion and the provinces which were carved from them. However, only Marawi City and Basilan, with the exception of Isabela City, opted to be integrated in the region.

The 2001 rebellion of the Moro National Liberation Front Misuari faction against the Philippine government during the presidency of Gloria Macapagal Arroyo was led by Nur Misuari, the founder of the Moro National Liberation Front (MNLF). It began on November 19, 2001 when members of a faction of the MNLF loyal to Misuari attacked a Philippine Army headquarters in Jolo, Sulu in the Philippines. The attack was meant to disrupt the Autonomous Region in Muslim Mindanao elections scheduled for November 26 of that year, which eventually replaced Misuari as governor.

Typhoon Chebi, known in the Philippines as Typhoon Emong was a typhoon that formed in June 2001.
The Second EDSA Revolution, also known as EDSA II, was a political protest from January 17–20, 2001 that peacefully overthrew the government of Joseph Estrada, the thirteenth President of the Philippines. Estrada resigned and was succeeded by his Vice President, Gloria Macapagal Arroyo, who was sworn into office by then-Chief Justice Hilario Davide Jr. at around noon on January 20, 2001, several hours before Estrada fled Malacañang Palace. EDSA is an acronym derived from Epifanio de los Santos Avenue, the major thoroughfare connecting five cities in Metro Manila, namely Pasay, Makati, Mandaluyong, Quezon City, and Caloocan, with the revolution's epicenter at the EDSA Shrine church at the northern tip of Ortigas Center, a business district.

The May 1 riots, or EDSA III, were protests sparked by the arrest of newly deposed president Joseph Estrada of the Philippines from April 25–May 1, 2001. The protest was held for seven days in a major highway in Metropolitan Manila, the Epifanio de los Santos Avenue (EDSA), which eventually culminated in an attempt to storm Malacañang. Taking place four months after the EDSA Revolution of 2001, the protests were considered as a more populist and representative uprising in comparison to the previous demonstrations in the same location in January 2001. The protests and the attack on the presidential palace, however, failed in their objectives. Participants continue to claim that it was a genuine People Power event, a claim disputed by the participants and supporters of EDSA II. President Gloria Macapagal Arroyo has acknowledged the divisive nature of the two terminologies by saying in one statement that she hoped to be the president of "EDSA II and EDSA III".

The Inauguration of Gloria Macapagal Arroyo as the fourteenth President of the Philippines occurred on January 20, 2001 under extraordinary circumstances. The inauguration marked the commencement of the first term of Gloria Macapagal Arroyo as President, during the EDSA Revolution of 2001 following the removal of President Joseph Estrada.

The Presidency of Joseph Estrada, also known as the Estrada Administration in the Philippines spanned for 31 months from June 30, 1998 to January 20, 2001. Estrada reached the pinnacle of his political career when he was elected President of the Republic in the May 11, 1998 national elections. With almost 11 million Filipinos writing his name on the ballot, his margin of victory was the biggest ever registered in Philippine electoral history.

Typhoon Lingling, known in the Philippines as Typhoon Nanang, was a typhoon that struck the Philippines and China in 2001. The name "Lingling" named by Hong Kong, and it is a female names.

Miss Earth 2001 was the first edition of Miss Earth pageant, organized by Carousel Productions. The pageant coronation night was held on 28 October 2001 at the University of the Philippines Theater in Quezon City, Philippines. There were 42 delegates who competed in the pageant that focuses on environmental issues. Catharina Svensson of Denmark, a professional equestrienne, fashion model, and third year law student, was crowned as the pageant's first winner.

The trial of Philippine president Joseph Estrada took place between 2001 and 2007 at the Sandiganbayan. Estrada, popularly called Erap, was ousted from office in 2001 during a popular uprising in Metro Manila after an aborted impeachment trial in which he was charged with plunder and perjury. Soon after his ouster, the same charges were filed against him at the Sandiganbayan.

Severe Tropical Storm Utor, known in the Philippines as Feria, was a storm that formed in 2001.