
Many of the tropes of science fiction can be viewed as similar to the goals of transhumanism. Science fiction literature contains many positive depictions of technologically enhanced human life, occasionally set in utopian societies. However, science fiction's depictions of technologically enhanced humans or other posthuman beings frequently come with a cautionary twist. The more pessimistic scenarios include many dystopian tales of human bioengineering gone wrong.

Alita: Battle Angel is a 2019 American cyberpunk action film based on Japanese manga artist Yukito Kishiro's 1990s series Battle Angel Alita and its 1993 original video animation adaptation, Battle Angel. It was directed by Robert Rodriguez, produced by James Cameron and written by Cameron and Laeta Kalogridis. Rosa Salazar stars through performance-capture animation as Alita, a cyborg who awakens in a new body with no memory of her past and sets out to uncover her destiny. Christoph Waltz, Jennifer Connelly, Mahershala Ali, Ed Skrein, Jackie Earle Haley and Keean Johnson star in supporting roles.

Galaxy Express 999 is a Japanese manga series written and illustrated by Leiji Matsumoto, later adapted into a number of anime films and television series. It is set in a spacefaring, high-tech future in which humans have learned how to transfer their minds and emotions with perfect fidelity into mechanical bodies, thus achieving practical immortality.

Max Headroom is an American satirical science fiction television series by Chrysalis Visual Programming and Lakeside Productions for Lorimar-Telepictures that aired in the United States on ABC from March 31, 1987 to May 12, 1988. The series is set in a futuristic dystopia ruled by an oligarchy of television networks, and features the character and media personality Max Headroom. The story is based on the Channel 4 British TV film produced by Chrysalis, Max Headroom: 20 Minutes into the Future.

"My Name Is Dark" is a song by Canadian musician Grimes. It was released on November 29, 2019 and is the third single from her fifth studio album Miss Anthropocene. The original title was "That's What the Drugs are For". A lyric video was published on December 3, 2019 featuring the Algorithm Mix of the song. Another lyric video was published on May 22, 2020, featuring a Russian translation and the Art Mix version. The video was released with the "Darkseid" lyrics. The composition consists of the industrial sound found on the Miss Anthropocene album combined with guitar and the soft-loud structure found in grunge music, including the song “Bullet with Butterfly Wings” by The Smashing Pumpkins which is also referenced in the lyrics, along with themes of nihilism, intoxication and spirituality.

Robotrix is a 1991 Hong Kong science fiction exploitation film directed by Jamie Luk Kin-ming and produced by the Golden Harvest Company. Bill Lui, the winner of the 23rd Hong Kong Film Awards, is the Art Director of this film. It features Taiwanese-American actor David Wu, Japanese attress Chikako Aoyama, kung fu expert Billy Chow, Hui Hsiao-dan, and the voluptuous soft-porn star Amy Yip. The plot concerns a female police officer who is gunned down, only to have her mind transferred into a cyborg clone. The idea of mind uploading as well as some cult elements inside the film make Robotrix become a science fiction film classic in Hong Kong.

State of Mind is a 2018 graphic adventure game developed and published by Daedalic Entertainment. A cyberpunk story set in the near future, the game explores transhumanist themes. The main character in the game, Richard Nolan, is voiced by Doug Cockle, most notable for being the voice actor of Geralt of Rivia in The Witcher video game series.

"We Appreciate Power" is a song by Grimes, featuring American musician Hana. It was released on November 29, 2018, billed as the lead single from her fifth studio album Miss Anthropocene, however it is only available on the Japanese and digital releases. The song was written and produced by Grimes, Hana and Chris Greatti.