
Adams Fall is writer Sean Desmond's first novel. It recounts the events which occur to a college student in his senior year at Harvard University. In the midst of completing his thesis and applying for a study abroad program, the narrator copes with his stresses by resorting to alcohol and drugs.

After You'd Gone is Northern Irish author Maggie O'Farrell's debut novel. Published in 2000 by Headline Review it garnered 'international acclaim' and won a Betty Trask Award.

Ama: A Story of the Atlantic Slave Trade is the debut historical novel by Manu Herbstein. It has been described as a work of faction that "successfully blends extensive and meticulous research with abundant imagination to transport the reader into the violent world of the Atlantic Slave Trade."

Back Roads is the 1999 novel by the American writer Tawni O'Dell, and was chosen as an Oprah's Book Club selection in March 2000.

Birdman (1999) was the first novel of British crime-writer Mo Hayder. It introduced her protagonist DI Jack Caffery.

Black Dog is the debut novel by author Stephen Booth in the Cooper and Fry series of novels, set in the Peak District. Black Dog won the 2001 Barry Award for the Best British Crime Novel.

Carbon Dreams is a novel by Susan M. Gaines and an example of what has come to be known as Lab lit or "science in fiction". It was published by Creative Arts Book Company in 2000 and is Gaines' first novel.

The Curry Mile is a 2006 novel written by Manchester-based British Pakistani novelist, Zahid Hussain. The debut novel was also the first book published by Suitcase Press. The book is set on Wilmslow Road, also known as the Curry Mile, in the Rusholme area of Manchester. The novel is a piece of urban realism written in dual narrative. It charts the life of a Pakistani family in the restaurant trade.

Death of a Red Heroine is a mystery novel written by Qiu Xiaolong and was published in English in 2000. It won the 2001 Anthony Award for best first novel.

The Dressmaker is a Gothic novel written by the Australian author Rosalie Ham, and is Ham's debut novel. It was first published by Duffy & Snellgrove on January 1, 2000. The story is set in a 1950s fictional Australian country town, Dungatar, and explores love, hate and haute couture.

e is a comic novel by Matt Beaumont first published in 2000. Written in the epistolary tradition, it consists entirely of e-mails written between the employees of an advertising agency and some of their business partners. Thus, the novel is a multiple-perspective narrative where events are seen through the eyes of various people working for the agency, from temp to CEO. e centres on corporate business structures, leadership, creativity, headhunting for and firing people to keep up appearances, work efficiency, business ethics, and all kinds of human weaknesses which stall progress by having employees waste their time and energy on unimportant things and which eventually prevent success.

The Fast Red Road: A Plainsong serves as Stephen Graham Jones's debut novel written in 2000. He only started writing the book after being introduced to Houghton-Mifflin editor Janet Silver at a party and telling a complicated lie about a book he had written.

Floodland is a children's fantasy novel by Marcus Sedgwick, published on 2 March 2000 by Orion Children's Books. Floodland won the Branford Boase Award in 2001 for an outstanding first published novel.

Goats is a 2000 novel written by Mark Jude Poirier published by Hyperion with the strapline "Girls, ganga and goat-trekking"

Grits is the debut novel by British author Niall Griffiths, published in 2000 by Jonathan Cape. Set in and around Aberystwyth and concerning promiscuity, drugs, alcohol, and petty crime it gained for its author, who lives and works in the town the dubious honorific "the Welsh Irvine Welsh". The novel is largely autobiographical, Griffiths moved to Aberystwyth to research a PhD in post-war British poetry but soon became, as he puts it, an "enthusiastic participator in parties" and dropped out of his studies.

The Hiding Place was the debut novel of Trezza Azzopardi, and was shortlisted for the Booker Prize in 2000. It tells the story of the six daughters of a Maltese family growing up in Cardiff through the eyes of the youngest, Dolores Gauci. She describes her childhood life

House of Leaves is the debut novel by American author Mark Z. Danielewski, published in March 2000 by Pantheon Books. A bestseller, it has been translated into a number of languages, and is followed by a companion piece, The Whalestoe Letters.

The Ice Harvest is the debut novel of Scott Phillips. The story, set in 1979, was published to wide acclaim in 2000.

The King's Peace is a fantasy novel by Welsh-Canadian writer Jo Walton, published by Tor Books in October 2000. The first of Walton's published novels, it is also the first of three "Sulien" novels. It was followed in 2001 by a sequel, The King's Name, and in 2002 by a prequel, The Prize in the Game. The novels are a reinterpretation of the story of King Arthur.

The Last Samurai (2000) is the first novel by American writer Helen DeWitt. It was sold in more than a dozen countries, with 100,000 copies sold in English. It was reissued by New Directions in 2016.

Layer Cake is the debut novel of British author J. J. Connolly, first published in 2000 by Duckworth Press. It was made into a motion picture in 2004, directed by Matthew Vaughn and written for the screen by Connolly himself.

Light House: A Trifle, a 2000 satirical novel by American screenwriter William Monahan. Originally serialized in the Amherst literary magazine Old Crow Review from 1993 to 1995, Monahan sold Light House to Riverhead Books, a Penguin Group imprint, in 1998. Warner Bros. optioned the film rights while the novel was in manuscript and hired Monahan to write the screenplay adaptation. The novel was delayed for two years, with plans to release it alongside the upcoming film; however, the film was never produced.

Moth Smoke is a novel written by Mohsin Hamid, published in 2000. It tells the story of Darashikoh Shezad, a banker in Lahore, Pakistan, who loses his job, falls in love with his best friend's wife, and plunges into a life of drugs and crime. It uses the historical trial of the liberal Mughal prince Dara Shikoh by his brother Aurangzeb as an allegory for the state of Pakistan at the time of the 1998 nuclear tests.

The Plantation was the first novel by Chris Kuzneski. First published in 2000, it introduced the characters of Jonathon Payne and David Jones, who have been featured in all of Kuzneski's thrillers. The book was endorsed by several notable authors, including James Patterson, Nelson DeMille, Lee Child, and James Rollins.

Pobby and Dingan is a novella by English author Ben Rice, which first appeared in issue 70 of Granta in Summer 2000 and published in book form later that year. It was joint winner of the 2001 Somerset Maugham Award and shortlisted for the John Llewellyn Rhys Prize. It has been made into the 2006 film Opal Dream, a 2010 play for children by Catherine Wheels Theatre Company and a 2012 play The Mysterious Vanishment Of Pobby & Dingan for Bristol theatre company Travelling Light.

Revelation Space is a 2000 science fiction novel by Welsh author Alastair Reynolds. It was the first novel set in Reynolds's eponymous universe. The novel reflects Reynolds's professional background: he has a PhD in astronomy and worked for many years for the European Space Agency. It was short listed for the 2000 BSFA and Arthur C. Clarke Awards.

A Riddle of Roses is the debut novel of Caryl Cude Mullin. It was illustrated by Kasia Charko and released by Second Story Press in 2000. The novel is well suited for young readers and marketed for young teenagers. The novel's topic is influenced by Celtic mythology and Arthurian legends.

The Toy Collector is a novel written by James Gunn, published by Bloomsbury Publishing in 2000. It is the story of a hospital orderly who steals drugs from the hospital which he sells to help keep his toy collection habit alive.

Triple Door is the first novel by Chinese writer Han Han.

Ventus is a 2000 science fiction/fantasy novel by Karl Schroeder. It was Schroeder's debut solo novel, and introduced his concept of thalience. The novel is available for free under the Creative Commons license at Schroeder's website. Its prequel, Lady of Mazes, was published in 2005.

Walkups is the debut novella by the Canadian author Lance Blomgren, published by Conundrum Press. The first printing quickly sold out following its release, having already been excerpted in various magazines and on the internet. It was followed by a companion piece, Corner Pieces in 2004. The novel has since been translated into French by Éditions Adage, translated by Elizabeth Robert, and published as Walkups: Scènes de la vie Montréalaise. A second printing of the novella was released by conundrum press in May 2009.

War Boy is the first novel by Kief Hillsbery, published in 2000 by Rob Weisbach Books, an imprint of William Morrow and Company.

White Teeth is a 2000 novel by the British author Zadie Smith. It focuses on the later lives of two wartime friends—the Bangladeshi Samad Iqbal and the Englishman Archie Jones—and their families in London. The novel is centred around Britain's relationships with people from formerly colonised countries in Africa, Asia, and the Caribbean.