
2312 is a science fiction novel by American writer Kim Stanley Robinson, published in 2012. It is set in the year 2312 when society has spread out across the Solar System. The novel won the 2013 Nebula Award for Best Novel.

Annabel is a 2010 novel by Canada-based author Kathleen Winter.

The Final Programme is a novel by British science fiction and fantasy writer Michael Moorcock. Written in 1965 as the underground culture was beginning to emerge, it was not published for several years. Moorcock has stated that publishers at the time considered it was "too freaky".

Golden Boy is the second novel by Abigail Tarttelin, published in 2013 about an intersex teenager, Max, and his family. It was described as a "dazzling debut" by Oprah's Book Club.

The Left Hand of Darkness is a science fiction novel by U.S. writer Ursula K. Le Guin. Published in 1969, it became immensely popular, and established Le Guin's status as a major author of science fiction. The novel is set in the fictional Hainish universe as part of the Hainish Cycle, a series of novels and short stories by Le Guin, which she introduced in the 1964 short story "The Dowry of the Angyar". It was fourth in sequence of writing among the Hainish novels, preceded by City of Illusions, and followed by The Word for World Is Forest.

The Looming Fog is the 2006 debut novel by the Nigerian writer, Rosemary Esehagu. The story follows the life of an intersex child as they struggle to live in a pre-colonial village in Nigeria that considers the anomaly an abomination.

Middlesex is a Pulitzer Prize-winning novel by Jeffrey Eugenides published in 2002. The book is a bestseller, with more than four million copies sold since its publication. Its characters and events are loosely based on aspects of Eugenides' life and observations of his Greek heritage. It is not an autobiography; unlike the protagonist, Eugenides is not intersex. The author decided to write Middlesex after reading the 1980 memoir Herculine Barbin and was dissatisfied with its discussion of intersex anatomy and emotions.

The Ministry of Utmost Happiness is the second novel by Indian writer Arundhati Roy, published in 2017, twenty years after her debut, The God of Small Things.

None of the Above is a novel by I. W. Gregorio, published in 2015 about an adolescent intersex girl, Kristin, who discovers she has an intersex condition shortly after becoming Homecoming Queen.

Son of Man is a science fiction novel by American writer Robert Silverberg, published in 1971. The book is about Clay, a 20th-century man, who travels billions of years into the future and meets humanity in its future forms. Some of the issues discussed in the book are sexuality, telepathic communication between people, physical prowess or frailty, division of humans by caste or ability, and the preservation of ancient wisdom, among other things.

The World Wreckers is a science fantasy novel by American writer Marion Zimmer Bradley, part of her Darkover series. First published by Ace Books in 1971, it features a complex sub-plot involving the sexual interactions between hermaphrodite native species, known as the chieri, and humans.