
The Commissioner of Internal Revenue is the head of the Internal Revenue Service (IRS), an agency within the United States Department of the Treasury.

George Sewall Boutwell was an American politician, lawyer, and statesman from Massachusetts. He served as Secretary of the Treasury under U.S. President Ulysses S. Grant, the 20th Governor of Massachusetts, a Senator and Representative from Massachusetts and the first Commissioner of Internal Revenue under U.S. President Abraham Lincoln. He was a leader in the impeachment of U.S. President Andrew Johnson.
Mortimer Maxwell Caplin was an American lawyer and educator, and the founding member of Caplin & Drysdale, Chartered.

Sheldon Stanley Cohen was an American attorney who served as the Commissioner of Internal Revenue from 1965 to 1969.

Columbus Delano was a lawyer, rancher, banker, statesman and a member of the prominent Delano family. Forced to live on his own at an early age, Delano struggled to become a self-made man. Delano was elected U.S. Congressman from Ohio, serving two full terms and one partial one. Prior to the American Civil War, Delano was a National Republican and then a Whig; as a Whig, he was identified with the faction of the party that opposed the spread of slavery into the Western territories, and he became a Republican when the party was founded as the major anti-slavery party after the demise of the Whigs in the 1850s. During Reconstruction Delano advocated federal protection of African-Americans' civil rights, and argued that the former Confederate states should be administered by the federal government, but was not part of the United States until they met the requirements for readmission to the Union.

Walter Evans was a United States Representative from Kentucky and a United States District Judge of the United States District Court for the District of Kentucky and of the United States District Court for the Western District of Kentucky.

Mark Whitty Everson is an American politician who is currently the Vice Chairman of alliantgroup and served as the 46th Commissioner of Internal Revenue from 2003 until 2007. Prior to his appointment as Commissioner of the IRS, Everson held a number of federal government positions in the administrations of George W. Bush and Ronald Reagan, as well as at the state level within the administration of Indiana Governor Mitch Daniels.

John Stephens Graham was a Washington, D.C. attorney and political appointee. He was an Assistant Secretary of the Treasury, and commissioners for the Internal Revenue Service and Atomic Energy Commission.

Guy Tresillian Helvering was a United States Representative from Kansas, Commissioner of Internal Revenue and a United States District Judge of the United States District Court for the District of Kansas.

John Andrew Koskinen is an American businessman and public official of Finnish descent. He served as the non-executive chairman of Freddie Mac from September 2008 to December 2011, retiring from the board in February 2012. On December 20, 2013, Koskinen was confirmed by the U.S. Senate to head the Internal Revenue Service (IRS) as Commissioner of Internal Revenue. On December 23, 2013, Koskinen was sworn in as the 48th IRS Commissioner after being nominated by President Barack Obama. His term ended on November 12, 2017, with David Kautter becoming his interim replacement, followed by Charles P. Rettig as his permanent replacement.

Joseph J. Lewis was the 2nd IRS commissioner.

William Orton was an American businessman who served as president of the Western Union Telegraph Company.

Alfred Pleasonton was a United States Army officer and major general of volunteers in the Union cavalry during the American Civil War. He commanded the Cavalry Corps of the Army of the Potomac during the Gettysburg Campaign, including the largest predominantly cavalry battle of the war, Brandy Station. In 1864, he was transferred to the Trans-Mississippi Theater, where he defeated Confederate General Sterling Price in two key battles, including the Battle of Mine Creek, the second largest cavalry battle of the war, effectively ending the war in Missouri. He was the son of Stephen Pleasonton and younger brother of Augustus Pleasonton.

Daniel Darwin Pratt was a United States Senator from Indiana. Born in Palermo, Maine, he moved to New York with his parents, who settled in Fenner. He attended the public schools and Cazenovia Seminary, and graduated from Hamilton College in 1831. He moved to Indiana in 1832 and taught school; in 1834, he settled in Indianapolis and was employed in the office of the Secretary of State. He studied law and was admitted to the bar, commencing practice in Logansport in 1836.

Green Berry Raum was a lawyer, author, and U.S. Representative from Illinois, as well as a brigadier general in the Union Army during the American Civil War. He served in the Western Theater, seeing action in several major battles while leading first an infantry regiment and then a brigade. He also presided over the Internal Revenue Service for seven years and was a prolific author of historical non-fiction books concerning politics and general Illinois history.

Charles Paul Rettig is an American attorney, currently serving as the United States Commissioner of Internal Revenue, the head of the U.S. Internal Revenue Service (IRS). On September 12, 2018, the United States Senate confirmed Rettig's nomination to be Commissioner for the term expiring November 12, 2022. Rettig was sworn in on October 1, 2018.

Edward Ashton Rollins was an American lawyer, banker, and politician that served as the 4th Commissioner of Internal Revenue from 1865 to 1869. Rollins also served as the Speaker of the New Hampshire House of Representatives from 1861 to 1862.

Nathan Bay Scott was a United States Senator from West Virginia.

Douglas H. "Doug" Shulman is President and Chief Executive Officer of OneMain Financial. Shulman is a former U.S. Commissioner of Internal Revenue.

Randolph William Thrower was an American attorney. He served as Commissioner of Internal Revenue under President Richard Nixon from 1969 to 1971.

Daniel I. Werfel is a Managing Director and Partner at Boston Consulting Group (BCG). He leads BCG's Public Sector Practice in North America. He formerly served as Acting Commissioner of the Internal Revenue Service of the United States. He served as the Acting Controller of the Office of Management Budget during the Administration of George W. Bush. In August 2009, President Obama nominated him to be the OMB Controller. The U.S. Senate confirmed him for the position of OMB Controller on October 13, 2009. In January 2011, while retaining the responsibilities of OMB Controller, he also took on the responsibilities of the OMB Deputy Director for Management. He worked as the Controller and Acting Deputy Director for Management until May 2013 at which time he was appointed as the Acting IRS Commissioner.