
Agatha Christie: The ABC Murders is a point-and-click adventure mystery video game developed by Artefacts Studio and published by Anuman under their Microïds brand for Microsoft Windows, Linux, Mac OS X, PlayStation 4 and Xbox One in February 2016. It was later released for Nintendo Switch in October 2020.

AI: The Somnium Files is an adventure video game developed and published by Spike Chunsoft, which released for Microsoft Windows, PlayStation 4, and Nintendo Switch in September 2019. It is set in Tokyo and follows detective Kaname Date, who investigates serial killings and enters suspects' memories to extract information to help solve them. The game was directed and written by Kotaro Uchikoshi, with character designs by Yūsuke Kozaki.

Analogue: A Hate Story is a visual novel created by independent designer and visual novelist Christine Love. It was created with the Ren'Py engine, and was first released for download on the author's website in February 2012. A sequel set centuries after Love's earlier work, Digital: A Love Story (2010), Analogue revolves around an unnamed investigator, who is tasked with discovering the reason for an interstellar ship's disappearance once it reappears after 600 years. The game's themes focus similarly around human/computer interaction, interpersonal relationships, and LGBT issues; but focus primarily on "transhumanism, traditional marriage, loneliness and cosplay."

Atamania (アタマニア) is a series of casual puzzle video games published by Level-5. The series comprises two, unrelated series of puzzle games. Tago Akira no Taisō|多湖輝の頭の体操||Professor Tago's Mental Gymnastics}} is a collection of puzzles created by Akira Tago, a Japanese professor who has authored a series of books within Japan under the same name. Players read through stories and solve puzzles at their own leisure. Surōn to Makuhēru no Nazo no Sutōrī is based on the concept of lateral thinking puzzles, books authored by Paul Sloane and Des MacHale. The games have drawn comparison to the Professor Layton series, which is also published by Level-5.

Black Closet is a mystery visual novel, strategy RPG and life simulation game developed and published by Hanako Games and released on September 16, 2015 for Windows, Mac OS X and Linux on the digital distribution service Steam.

Bokuhime Project is a mystery adventure video game developed by Wizard Soft, and published by Nippon Ichi Software on April 23, 2020 in Japan for the Nintendo Switch and PlayStation 4. The player takes the role of a young man who infiltrates a school for refined young ladies by enrolling as a female student to investigate an incident involving his sister. As part of their investigation, the player aims to get a seat in an influential organization at the school, and thereby needs to improve their character statistics to raise their character's cuteness, overcoming the other candidates.

Caper in the Castro is a murder mystery video game developed by C.M. Ralph and released in 1989. It is the earliest known computer game to focus on LGBT themes. The game was originally released for Mac computers and distributed freely on bulletin board systems as charityware to raise money for the AIDS epidemic.

Case Closed: The Mirapolis Investigation, known in Japan as Meitantei Conan: Tsuioku no Mirage , is a video game for the Wii. It is based upon the popular anime and manga series Case Closed by Gosho Aoyama. Players use the Wii Remote to find clues and solve the cases.

The ClueFinders is an educational software series aimed at children from age 8-12 that features a group of mystery-solving teens. The series was created by The Learning Company as a counterpart to their Reader Rabbit series for older, elementary-aged students. The series has received praise for its balance of education and entertainment, resulting in numerous awards won.

The Colonel's Bequest is a character-driven graphic adventure game by Sierra On-Line. It was developed for MS-DOS in 1989. Ports for Amiga and Atari ST were released in 1990. It was the first of the short-lived Laura Bow Mysteries series created by Roberta Williams, which used many elements from the game Mystery House and is known for its lack of discernible point system. The Colonel's Bequest was created with SCI0, and employed 4-bit color and a typing interface. Its sequel The Dagger of Amon Ra was released in 1992.

Cyber Danganronpa VR: The Class Trial is a free-to-play virtual reality tech demo in the Danganronpa series, developed and published by Spike Chunsoft for the PlayStation 4 for use with the PlayStation VR virtual reality headset. It was produced by Yoshinori Terasawa at Spike Chunsoft, who was inspired to create the game after playing Bandai Namco Entertainment's Summer Lesson.

Danganronpa: Trigger Happy Havoc is a visual novel adventure game developed and published by Spike as the first game in the Danganronpa series. The game was originally released in Japan for the PlayStation Portable in November 2010 and was later ported to Android and iOS in August 2012. Danganronpa was localized and published in English regions by NIS America in February 2014, and for PC, Mac and Linux in February 2016.

Danganronpa 2: Goodbye Despair is a visual novel adventure game developed by Spike Chunsoft. It is the second game in the Danganronpa franchise, following 2010's Danganronpa: Trigger Happy Havoc. It was first released in Japan for the PlayStation Portable in July 2012, with a port released for the PlayStation Vita in Japan in October 2013, and worldwide by NIS America in September 2014. A port for personal computers was also released in April 2016, as well as a bundle containing the first Danganronpa for the PlayStation 4 in March 2017, called Danganronpa 1-2 Reload.

Danganronpa V3: Killing Harmony is a visual novel adventure game developed by Spike Chunsoft for the PlayStation 4, PlayStation Vita and Windows. The game was released in Japan in January 2017, and in North America and Europe by NIS America that September. A Windows version was also released at the same time.

Dead Secret is a first-person horror mystery game. It was created by Robot Invader and was released on 29 October 2015. The game is set in 1965 and the main story line revolves around the murder of Harris Bullard.

Divi-Dead is a Japanese 2D adult game released by C's Ware in 1998. The game's theme falls into the category of adult horror, as it deals with supernatural and sexual topics. Certain images from the game are brutally violent and strange, while others are lighthearted and erotic. It is a visual novel that involves a supernatural mystery which the player solves in order to complete the game. The player makes certain decisions throughout the story, which may lead to different endings for the game. An English translation was released by Himeya Soft.

Escape Dead Island is an adventure survival horror video game developed by Swedish developer Fatshark, published by German studio Deep Silver and distributed by Square Enix in North America for PS3 and Xbox 360 and Valve for PC. It is the second Dead Island spin-off.

EVE Burst Error is a 1995 erotic visual novel adventure game developed by C's Ware. It was written and produced by Hiroyuki Kanno, with chiptune video game music composed by Ryu Umemoto.

Firewatch is an adventure game developed by Campo Santo and published by the developer in partnership with Panic. The game was released in February 2016 for Microsoft Windows, OS X, Linux, and PlayStation 4, for Xbox One in September 2016, and for Nintendo Switch in December 2018.

Ghost Whisperer is a casual hidden-object mystery adventure game developed by Legacy Games for Microsoft Windows and Mac OS. The game is based on the CBS supernatural television drama Ghost Whisperer starring Melinda Gordon. The game contains two different cases to solve: "Forgotten Toys" and "A Brush with Death".

The Hardy Boys: The Hidden Theft is the first title in The Hardy Boys PC game series created by JoWood Productions and The Adventure Company. It was based on The Tower Treasure, the first book in the book series. The game was released September 30, 2008. A sequel was made called The Hardy Boys: The Perfect Crime; this Hidden Object game was critically panned.

Les Manley in: Lost in L.A. is the second game in the Les Manley series of adult-themed graphical adventure games. It is often compared to the Leisure Suit Larry game series as both are adult-themed adventure games with a male protagonist. Different from its predecessor Search for the King which used a text parser, Lost in L.A. is a point-and-click adventure game. In 2020, Ziggurat Interactive acquired the publishing rights and re-released the game as a digital download on GOG.com.

Murder by Numbers is a video game developed by Mediatonic and published by The Irregular Corporation. It was released on March 5, 2020 for Nintendo Switch and Windows. The game is a hybrid of visual novels with nonogram-style logic puzzles to progress the story.

Mystery Case Files is a video game series originally developed by the internal studios of Big Fish Games. Some installments was developed by Eipix Entertainment between 2015 to 2019 and Elephant Games who developed sequels from 2013 to 2014. Now, the newest installments were developed by GrandMA Studios. The Mystery Case Files series is known for its ‘Hidden Object’ puzzles where, in order to progress through a game, the player plays the role of a Master Detective and must find a certain number of items hidden somewhere on a painted scene.

Otogirisō is a visual novel made by Chunsoft.

Panic in the Park is an Interactive movie adventure video game developed by Imagination Pilots in and published by WarnerActive in 1995. The game stars Erika Eleniak as both Jamie and Janie in the game and Michael Clarke Duncan as a security guard. There are around 30 actors in the cast. The was going to be ported to Macintosh, but that port never came to being released.

Return of the Obra Dinn is a puzzle video game created by Lucas Pope. It was his second commercial game, following 2013's Papers, Please, and was released for macOS and Microsoft Windows in October 2018, and with ports for the Nintendo Switch, PlayStation 4, and Xbox One releasing a year later.

Virtual Murder is a four-part murder mystery adventure video game series developed by Creative Multimedia Corporation. The games were released in 1993 and 1994 for Macintosh and Windows PCs.

Who Framed Roger Rabbit is a 1991 overhead adventure game by Capcom for the Game Boy released in North America and Europe. Based on the 1988 film of the same title, it is one of the earliest games designed by Shinji Mikami.

The Wolf Among Us is an episodic graphic adventure game based on Bill Willingham's Fables comic book series. It is developed by Telltale Games. It is canon with the comic book universe and is set as a prequel to the comic book. The game consists of five episodes that were released throughout 2013. Retail versions for the PlayStation 3, PlayStation 4, PlayStation Vita, Xbox 360, and Xbox One consoles were released in November 2014.