
The Annunciation with St. Margaret and St. Ansanus is a painting by the Italian Gothic artists Simone Martini and Lippo Memmi, now housed in the Uffizi Gallery in Florence, Italy. It is a wooden triptych painted in tempera and gold, with a central panel having double size. Considered Martini's masterwork and one of the most outstanding works of Gothic painting, the work was originally painted for a side altar in the Siena Cathedral.

The Cortona Triptych is a Catholic Church depiction of the Madonna and Child with saints, painted by Fra Angelico. It is now kept at the Diocesan Museum in Cortona, Italy. The painting dates from 1436–1437.

The Maestà, or Maestà of Duccio is an altarpiece composed of many individual paintings commissioned by the city of Siena in 1308 from the artist Duccio di Buoninsegna and is his most famous work. The front panels make up a large enthroned Madonna and Child with saints and angels, and a predella of the Childhood of Christ with prophets. The reverse has the rest of a combined cycle of the Life of the Virgin and the Life of Christ in a total of forty-three small scenes; several panels are now dispersed or lost. The base of the panel has an inscription that reads : "Holy Mother of God, be thou the cause of peace for Siena and life to Duccio because he painted thee thus." Though it took a generation for its effect truly to be felt, Duccio's Maestà set Italian painting on a course leading away from the hieratic representations of Byzantine art towards more direct presentations of reality.

Madonna Enthroned, also known as the Ognissanti Madonna, or just Madonna Ognissanti, is a painting by the Italian late medieval artist Giotto di Bondone, housed in the Uffizi Gallery of Florence, Italy.

The Perugia Altarpiece is a painting by the Italian early Renaissance painter Fra Angelico, housed in the Galleria Nazionale dell'Umbria of Perugia, Italy.
The Polyptych of the Misericordia is a painting conserved in the Museo Civico di Sansepolcro in the town of Sansepolcro, region of Tuscany, Italy. The painting is one of the earliest works of the Italian Renaissance painter Piero della Francesca, who was born in the town. The central panel is of the common motif of the Virgin of Mercy or Madonna della Misericordia.

The Rucellai Madonna is a panel painting representing the Virgin and Child enthroned with Angels by the Sienese painter Duccio di Buoninsegna. The original contract for the work is dated 1285; the painting was probably delivered in 1286. The painting was commissioned by the Laudesi confraternity of Florence to decorate the chapel they maintained in the Dominican church of Santa Maria Novella. It was transferred to the Galleria degli Uffizi in the 19th century. The Rucellai Madonna is the largest 13th-century panel painting extant.

The St. Peter of Verona Triptych is a painting by the Italian early Renaissance master Fra Angelico, executed around 1428–1429. It is housed in the National Museum of San Marco, Florence, region of Tuscany, Italy.

The Santa Trinita Maestà is a painting by the Italian medieval artist Cimabue, dating to c. 1290–1300. Originally painted for the church of Santa Trinita, Florence, where it remained until 1471, it is now housed in the Uffizi Gallery of Florence, Italy.

The Stefaneschi Altarpiece is a triptych by the Italian painter Giotto, commissioned by Cardinal Giacomo Gaetani Stefaneschi to serve as an altarpiece for one of the altars of Old St. Peter's Basilica in Rome.

The Valle Romita Polyptych is a painting by the Italian late Gothic painter Gentile da Fabriano, dating from c. 1410-1412 and now housed in the Pinacoteca di Brera in Milan. It was originally executed for the Franciscan hermitage of Valle Romita near Gentile's birthplace, Fabriano.