
Equestrian Portrait of the Duke of Lerma is a 1603 portrait of Francisco Gómez de Sandoval, 1st Duke of Lerma by Rubens, now in the Prado in Madrid.

Flowers with Two Lizards is a 1603 painting by Roelant Savery, now in the Centraal Museum in Utrecht. It and a near-identical version by the same artist are the two earliest surviving floral still lifes from the Northern Netherlands.

Heraclitus and Democritus is a 1603 painting by the Flemish artist Peter Paul Rubens. It is now held in the National Sculpture Museum in Valladolid. It shows the ancient Greek philosophers Heraclitus and Democritus.

Hercules and Omphale is a circa 1602 painting by Peter Paul Rubens, now held in the Louvre Museum in Paris.

Pietà with Two Angels is a c.1603 oil on copper painting by Annibale Carracci, now in the Kunsthistorisches Museum in Vienna.

Portable Altarpiece with Pietà and Saints is a 1603 oil on canvas painting by Annibale Carracci in a gold, ebony and copper frame. It is now in the Galleria Nazionale d'Arte Antica in Rome.

Portrait of a Young Woman is an unfinished painting of around 1603, attributed to Rubens. It may be connected with a commission from Vincenzo Gonzaga, Duke of Mantua mentioned in Rubens' letters, during the latter's time in Italy and Spain, to paint aristocratic Spanish ladies to add to the duke's 'gallery of beauties'. Its subject's name is unknown. Two red seals on its back place it in Venice early in the 19th century and then in the collection of Sir John Hanmer at Bettisfield Park in Wrexham by the 1840s.

The Sacrifice of Isaac is the title of two paintings from c. 1598 - 1603 depicting the sacrifice of Isaac. The paintings could be painted by the Italian master Caravaggio (1571–1610) but there is also strong evidence that they may have been the work of Bartolomeo Cavarozzi, a talented early member of the Caravaggio following who is known to have been in Spain about 1617–1619.

Saint Bernardino of Siena is a 1603 work by El Greco. It is owned by the Museo del Prado but displayed at the El Greco Museum in Toledo, Spain.

Sleeping Venus is a c. 1603 painting by Annibale Carracci held by the Musée Condé in Chantilly, Oise, France. This oil painting measures 190x328cm. It depicts Venus sleeping with her arm above her head as putti frolic around her. Carracci painted Sleeping Venus for Odoardo Farnese. Giovanni Battista Agucchi wrote an ekphrasis of this painting that Carlo Cesare Malvasia included in his book Life of the Carracci. In The Lives of the Modern Painters, Sculptors and Architects, Giovanni Pietro Bellori wrote a description of the painting that paraphrases Agucchi's ekphrasis without citation.